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System Introduction
Welcome to ARN
InIn total, 3102 genes and microRNAs, 1868 relations, and 33969 expression records associated with adipogenesis according to 1627 papers were collected. Additionally, we further determined 13103 possible relations of these nodes due to miRGate, miRBase, BioGRID, PAZAR and TRRUST. (On Feb 7, 2017)
More preparation may quicken the speed in doing work.
Therefore, please read the handbook first.
How to cite ARN:
ARN: Analysis and Visualization System for Adipogenic Regulation Network Information. Scientific Reports 6:39347 2016 Dec 16 (PMID: 27982098)
ARN: analysis and prediction by adipogenic professional database. BMC Syst Biol. 2016 Aug 8;10(1):57. (PMID: 27503118)
Handbook of ARN Database: English Version | Chinese Version
Adipogenesis Regulation Network
Chart Setting
Top 50 Nodes
# | Symbol | Classification | Function | Differentiation Direction | IF(%) | Links |
---|---|---|---|---|---|---|
1 | pparg | transcription factor | Transcription activation or inhibition | Pro-adipogenesis,Pro-Browning adipogenesis,Anti-osteoblastogenesis | 77.1 | 132 |
2 | cebpb | transcription factor | Transcription activation or inhibition | Pro-adipogenesis,Pro-Browning adipogenesis | 40.4 | 78 |
3 | runx2 | transcription factor | Transcription activation or inhibition | Pro-osteoblastogenesis | 28.4 | 65 |
4 | cebpa | transcription factor | Transcription activation or inhibition | Pro-adipogenesis | 40.7 | 52 |
5 | ctnnb1 | transcription factor,signal factor | Transcription activation or inhibition,Signal transduction | Anti-adipogenesis | 20.8 | 42 |
6 | stat3 | transcription factor,signal factor | Transcription activation or inhibition | Pro-adipogenesis,Pro-osteoblastogenesis | 34.7 | 36 |
7 | creb1 | transcription factor | Transcription activation or inhibition | Pro-adipogenesis,Pro-osteoblastogenesis | 23.9 | 34 |
8 | nfkb1 | transcription factor | Transcription activation or inhibition | 41.4 | 31 | |
9 | sirt1 | epigenetic modification factor | Epigenetic modification | Pro-Browning adipogenesis,Pro-myogenesis,Pro-osteoblastogenesis,Anti-adipogenesis | 16.5 | 31 |
10 | mapk1 | signal factor | Signal transduction | Pro-adipogenesis | 10.5 | 29 |
11 | srebf1 | transcription factor | Transcription activation or inhibition | Pro-adipogenesis,Pro-osteoblastogenesis,Osteoblast differentiation up | 27.6 | 29 |
12 | wnt | family | Signal transduction | 3.5 | 28 | |
13 | tnf | signal factor | Signal transduction | Anti-adipogenesis,Anti-myogenesis | 18.8 | 28 |
14 | mirn27a | miR | Bind to RNA | Pro-osteoblastogenesis,Anti-adipogenesis,Anti-osteoblastogenesis | 16.9 | 26 |
15 | obesity | environmental factor | Stimuli | Pro-adipogenesis | 6.3 | 25 |
16 | igf1 | signal factor,cell growth | Signal transduction | Pro-adipogenesis,Pro-myogenesis | 20.1 | 23 |
17 | ucp1 | metabolism | Metabolism and transport | Pro-Browning adipogenesis | 6.7 | 21 |
18 | ampk | family | Others | 5.1 | 20 | |
19 | age | environmental factor | Stimuli | Pro-adipogenesis | 5.1 | 20 |
20 | adipoq | signal factor,metabolism | Signal transduction | Pro-adipogenesis,Pro-Browning adipogenesis,Pro-osteoblastogenesis | 27.1 | 20 |
21 | ppargc1a | transcription factor | Transcription activation or inhibition | Pro-Browning adipogenesis | 16.3 | 19 |
22 | bmp2 | cell growth | Cell growth/cycle regulator | Pro-adipogenesis,Pro-osteoblastogenesis | 8.7 | 19 |
23 | klf15 | transcription factor | Transcription activation or inhibition | Pro-adipogenesis | 9.6 | 19 |
24 | sp7 | transcription factor | Transcription activation or inhibition | Pro-osteoblastogenesis,Anti-adipogenesis | 6 | 19 |
25 | mirn1 | miR | Bind to RNA | Pro-myogenesis | 14.7 | 18 |
26 | slc2a4 | metabolism | Metabolism and transport | Pro-adipogenesis | 13.6 | 18 |
27 | prdm16 | transcription factor,epigenetic modification factor | Transcription activation or inhibition,Epigenetic modification | Pro-Browning adipogenesis,Anti-myogenesis | 7.7 | 18 |
28 | cebpd | transcription factor | Transcription activation or inhibition | Pro-adipogenesis | 18.4 | 17 |
29 | tgfb1 | signal factor | Signal transduction | Anti-adipogenesis | 10.6 | 17 |
30 | ap1 | complex | Transcription activation or inhibition | 4.3 | 17 | |
31 | mirn143 | miR | Bind to RNA | Pro-adipogenesis,Anti-osteoblastogenesis | 14.1 | 16 |
32 | satb2 | transcription factor | Transcription activation or inhibition | Pro-osteoblastogenesis | 3.1 | 16 |
33 | gsk3b | signal factor | Signal transduction | Pro-adipogenesis,Anti-osteoblastogenesis | 8.1 | 16 |
34 | myod1 | transcription factor | Transcription activation or inhibition | Pro-myogenesis | 6 | 16 |
35 | mirn133 | miR | Bind to RNA | Pro-myogenesis | 4 | 16 |
36 | irs1 | signal factor | Signal transduction | Pro-adipogenesis | 11.6 | 15 |
37 | wnt10b | signal factor | Signal transduction | Pro-osteoblastogenesis,Anti-adipogenesis | 7.1 | 15 |
38 | pik3ca | signal factor | Signal transduction | Pro-adipogenesis | 6.4 | 15 |
39 | mirn133a | miR | Bind to RNA | Pro-myogenesis,Anti-osteoblastogenesis | 10.6 | 15 |
40 | lep | signal factor | Signal transduction | Anti-adipogenesis | 16 | 14 |
41 | ins | signal factor | Signal transduction | Pro-adipogenesis | 4.5 | 14 |
42 | yy1 | transcription factor | Transcription activation or inhibition | Pro-adipogenesis,Anti-myogenesis | 12.3 | 14 |
43 | atf4 | transcription factor | Transcription activation or inhibition | Pro-osteoblastogenesis | 11.5 | 14 |
44 | prb | cell growth | Cell growth/cycle regulator | Pro-adipogenesis | 3.8 | 14 |
45 | dlk1 | signal factor | Signal transduction | Pro-osteoblastogenesis,Anti-adipogenesis | 10.9 | 13 |
46 | stat1 | transcription factor,signal factor | Transcription activation or inhibition | Pro-osteoblastogenesis | 16.4 | 13 |
47 | mirn21 | miR | Bind to RNA | Pro-adipogenesis,Pro-osteoblastogenesis,Pro-osteoclastogenesis,Anti-osteoclastogenesis | 16.6 | 13 |
48 | gh1 | signal factor | Signal transduction | Pro-adipogenesis | 4.1 | 13 |
49 | il6 | signal factor | Signal transduction | 26.3 | 13 | |
50 | wnt3a | signal factor | Signal transduction | Anti-adipogenesis,Anti-osteoblastogenesis | 3.9 | 13 |