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System Introduction

Welcome to ARN

InIn total, 3102 genes and microRNAs, 1868 relations, and 33969 expression records associated with adipogenesis according to 1627 papers were collected. Additionally, we further determined 13103 possible relations of these nodes due to miRGate, miRBase, BioGRID, PAZAR and TRRUST. (On Feb 7, 2017)

More preparation may quicken the speed in doing work.

Therefore, please read the handbook first.

How to cite ARN:

ARN: Analysis and Visualization System for Adipogenic Regulation Network Information. Scientific Reports 6:39347 2016 Dec 16 (PMID: 27982098)

ARN: analysis and prediction by adipogenic professional database. BMC Syst Biol. 2016 Aug 8;10(1):57. (PMID: 27503118)

Handbook of ARN Database: English Version | Chinese Version

Adipogenesis Regulation Network

Chart Setting


Top 50 Nodes

# Symbol Classification Function Differentiation Direction IF(%) Links
1 pparg transcription factor Transcription activation or inhibition Pro-adipogenesis,Pro-Browning adipogenesis,Anti-osteoblastogenesis 77.1 132
2 cebpb transcription factor Transcription activation or inhibition Pro-adipogenesis,Pro-Browning adipogenesis 40.4 78
3 runx2 transcription factor Transcription activation or inhibition Pro-osteoblastogenesis 28.4 65
4 cebpa transcription factor Transcription activation or inhibition Pro-adipogenesis 40.7 52
5 ctnnb1 transcription factor,signal factor Transcription activation or inhibition,Signal transduction Anti-adipogenesis 20.8 42
6 stat3 transcription factor,signal factor Transcription activation or inhibition Pro-adipogenesis,Pro-osteoblastogenesis 34.7 36
7 creb1 transcription factor Transcription activation or inhibition Pro-adipogenesis,Pro-osteoblastogenesis 23.9 34
8 nfkb1 transcription factor Transcription activation or inhibition   41.4 31
9 sirt1 epigenetic modification factor Epigenetic modification Pro-Browning adipogenesis,Pro-myogenesis,Pro-osteoblastogenesis,Anti-adipogenesis 16.5 31
10 mapk1 signal factor Signal transduction Pro-adipogenesis 10.5 29
11 srebf1 transcription factor Transcription activation or inhibition Pro-adipogenesis,Pro-osteoblastogenesis,Osteoblast differentiation up 27.6 29
12 wnt family Signal transduction   3.5 28
13 tnf signal factor Signal transduction Anti-adipogenesis,Anti-myogenesis 18.8 28
14 mirn27a miR Bind to RNA Pro-osteoblastogenesis,Anti-adipogenesis,Anti-osteoblastogenesis 16.9 26
15 obesity environmental factor Stimuli Pro-adipogenesis 6.3 25
16 igf1 signal factor,cell growth Signal transduction Pro-adipogenesis,Pro-myogenesis 20.1 23
17 ucp1 metabolism Metabolism and transport Pro-Browning adipogenesis 6.7 21
18 ampk family Others   5.1 20
19 age environmental factor Stimuli Pro-adipogenesis 5.1 20
20 adipoq signal factor,metabolism Signal transduction Pro-adipogenesis,Pro-Browning adipogenesis,Pro-osteoblastogenesis 27.1 20
21 ppargc1a transcription factor Transcription activation or inhibition Pro-Browning adipogenesis 16.3 19
22 bmp2 cell growth Cell growth/cycle regulator Pro-adipogenesis,Pro-osteoblastogenesis 8.7 19
23 klf15 transcription factor Transcription activation or inhibition Pro-adipogenesis 9.6 19
24 sp7 transcription factor Transcription activation or inhibition Pro-osteoblastogenesis,Anti-adipogenesis 6 19
25 mirn1 miR Bind to RNA Pro-myogenesis 14.7 18
26 slc2a4 metabolism Metabolism and transport Pro-adipogenesis 13.6 18
27 prdm16 transcription factor,epigenetic modification factor Transcription activation or inhibition,Epigenetic modification Pro-Browning adipogenesis,Anti-myogenesis 7.7 18
28 cebpd transcription factor Transcription activation or inhibition Pro-adipogenesis 18.4 17
29 tgfb1 signal factor Signal transduction Anti-adipogenesis 10.6 17
30 ap1 complex Transcription activation or inhibition   4.3 17
31 mirn143 miR Bind to RNA Pro-adipogenesis,Anti-osteoblastogenesis 14.1 16
32 satb2 transcription factor Transcription activation or inhibition Pro-osteoblastogenesis 3.1 16
33 gsk3b signal factor Signal transduction Pro-adipogenesis,Anti-osteoblastogenesis 8.1 16
34 myod1 transcription factor Transcription activation or inhibition Pro-myogenesis 6 16
35 mirn133 miR Bind to RNA Pro-myogenesis 4 16
36 irs1 signal factor Signal transduction Pro-adipogenesis 11.6 15
37 wnt10b signal factor Signal transduction Pro-osteoblastogenesis,Anti-adipogenesis 7.1 15
38 pik3ca signal factor Signal transduction Pro-adipogenesis 6.4 15
39 mirn133a miR Bind to RNA Pro-myogenesis,Anti-osteoblastogenesis 10.6 15
40 lep signal factor Signal transduction Anti-adipogenesis 16 14
41 ins signal factor Signal transduction Pro-adipogenesis 4.5 14
42 yy1 transcription factor Transcription activation or inhibition Pro-adipogenesis,Anti-myogenesis 12.3 14
43 atf4 transcription factor Transcription activation or inhibition Pro-osteoblastogenesis 11.5 14
44 prb cell growth Cell growth/cycle regulator Pro-adipogenesis 3.8 14
45 dlk1 signal factor Signal transduction Pro-osteoblastogenesis,Anti-adipogenesis 10.9 13
46 stat1 transcription factor,signal factor Transcription activation or inhibition Pro-osteoblastogenesis 16.4 13
47 mirn21 miR Bind to RNA Pro-adipogenesis,Pro-osteoblastogenesis,Pro-osteoclastogenesis,Anti-osteoclastogenesis 16.6 13
48 gh1 signal factor Signal transduction Pro-adipogenesis 4.1 13
49 il6 signal factor Signal transduction   26.3 13
50 wnt3a signal factor Signal transduction Anti-adipogenesis,Anti-osteoblastogenesis 3.9 13