The precursor SREBP is embedded in the ER membrane in a complex with SCAP, and Insig interacts with SCAP (bound to cholesterol) and retains the SCAP/SREBP complex in the ER. Low sterol conditions result in dissociation of cholesterol from SCAP disrupting the SCAP-Insig interaction which leads to SCAP/SREBP transit through the COP II vesicle transport system to the golgi apparatus. There, SREBPs are cleaved sequentially by the S1P/S2P enzymes, the mature SREBP amino terminal fragment (N) is released and rapidly enters the nucleus where it activates target genes. Insulin/growth factor signaling (InsR) through AKT affects SREBP maturation, as shown by the arrows. Red and black arrows indicate inhibitory and stimulatory actions. The question marks indicate the mechanism for the effects still need to be defined. Torc1 feedback inhibition of InsR signaling is also shown.