Maps
SREBPs in the innate immune response
| Classification | signal factor |
| PMID | 22154484 |
The pathway whereby SREBP-1a is regulated by TLR4 signaling and stimulates Caspase-1 activity and IL-1β secretion is shown on the left. The involvement of interferon signaling (IRF) in regulating SREBP-2 is shown on the right. Both pathways are discussed in the text.
| # | Node Name | Symbol | # | Node Name | Symbol |
|---|---|---|---|---|---|
| 1 | TLR4 | tlr4 | 9 | TLR3 | tlr3 |
| 2 | NFkappaB | nfkb1 | 10 | TRIF | ticam1 |
| 3 | SREBP-1a | srebf1 | 11 | TLR9 | tlr9 |
| 4 | NLRP1a | nlrp1a | 12 | Myd88.IRF | myd88 |
| 5 | NLRP3 | nlrp3 | 13 | IFN-alpha | trim63 |
| 6 | Caspase1 | casp1 | 14 | IFN-beta | ifna1 |
| 7 | IL1R | il1r1 | 15 | IFNAR2 | ifnb1 |
| 8 | IL1-beta | il1b | 16 | IFNAR1 | ifnar2 |
Relation Chart
Chart Legend
