Node - Adipogenesis Regulation Network Database

NCBI Gene

Symbol	ccnd1	Gene ID	595
IF	26.2%	Link Number	3
Full Name	cyclin D1
Aliases	BCL1,D11S287E,PRAD1,U21B31,cyclin D1
Summary	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

Node Summary

PMID: 19581903

T cell-specific transcription factors (TCFs) to recruit a β‑catenin-dependent co-activator complex to activate target gene transcription. In the context of adipogenesis,these include cyclin D1 and the nuclear receptor COUP transcription factor II (COUP-TFII)32, although the role of COUP-TFII in adipogenesis is controversial.

Node Expression

#	PMID	Condition	Expression	Material
1	27385551	human preadipocyte dif (96 192) hours	(0 0.633629)	preadipocyte
2	27385551	human preadipocyte dif (0 384) hours	(0 -1.44844)	preadipocyte
3	27385551	human preadipocyte dif (0 192) hours	(0 -1.77925)	preadipocyte
4	27385551	human preadipocyte dif (0 48) hours	(0 -1.9744)	preadipocyte
5	27385551	human preadipocyte dif (6 48) hours	(0 -1.97827)	preadipocyte
6	27385551	human preadipocyte dif (0 96) hours	(0 -2.41288)	preadipocyte
7	27108396	Control VS hADSC day 21 post-adipogenic induction	(1 -3.95)	hADSC
8	27108396	Control VS hADSC day 14 post-adipogenic induction	(1 -4.97)	hADSC
9	27108396	Control VS hADSC day 7 post-adipogenic induction	(1 -2.8)	hADSC
10	26111340	hMSC uncommitted High expression	Up-Regulated	MSC
11	23967297	age-Eadi(6 14 18)M	age-adi(1 2.5 -1.6)	mouse
12	23967297	age-Badi(6 14 18)	age-adi(1 1.3 1.1)	mouse
13	23967297	E-adi(6 14 19)M	dif-age(1 2.48 -1.64)	mouse
14	23967297	B-adi(6 14 18)	dif-age(1 1.26 1.11)	mouse
15	12021175	Ratio(1 2 3 4 5)preadi/fibro,TZD-preadi/preadi,adi/fibro,adi/preadi,TZD-adi/adi	ratio(0 0 -1 -1 1）	3T3-L1
16	11445576		adipo-enriched	3T3-L1

Relation Chart

Chart Legend

Node
Relation

Relation Table (3 records)

Relation:

Type:

Method:

#	Source	IF(%)	Relation	Target	IF(%)	Type	Method	PMID
1	ccnd1	26.2	activates	hdac1	11.3	bind to protein	(IP)immunoprecipitation,Cell culture and differentiation,ChIP,Overexpression and knockdown,Western blot	15713663
2	ccnd1	26.2	activates	hdac3	4.1	bind to protein	(IP)immunoprecipitation,Cell culture and differentiation,ChIP,Overexpression and knockdown,Western blot	15713663
3	creb1	23.9	activates	ccnd1	26.2	bind to DNA	(IP)immunoprecipitation,Cell culture and differentiation,ChIP,Confocal microscopy,Methylation-specific PCR,Overexpression and knockdown,Reporter,RT-qPCR or RT-PCR,Western blot	18957421

Prediction Chart

Chart Legend

Prediction Table (115 records)

Species:

#	Source	IF(%)	Target	IF(%)	Species	Agreement	Computational Predictions / PMID
1	ar	22.7	ccnd1	26.2	Human	100.00	16921507
2	atf2	9.1	ccnd1	26.2	Human	100.00	10464245
3	bhlhe41	2.3	ccnd1	26.2	Human	100.00	18223678
4	brca1	29.8	ccnd1	26.2	Human	100.00	12032322
5	brca1	29.8	ccnd1	26.2	Human	100.00	12032322
6	brca1	29.8	ccnd1	26.2	Human	100.00	12032322
7	btg2	6.4	ccnd1	26.2	Human	100.00	15870875
8	ctnnb1	20.8	ccnd1	26.2	Human	100.00	17109766
9	ctnnb1	20.8	ccnd1	26.2	Human	100.00	16628468
10	e2f1	22.1	ccnd1	26.2	Human	100.00	20655656
11	e2f4	6.7	ccnd1	26.2	Human	100.00	9584162
12	egr1	21.1	ccnd1	26.2	Human	100.00	11502738
13	ep300	11.4	ccnd1	26.2	Human	100.00	20101207
14	esr1	17.1	ccnd1	26.2	Human	100.00	12554765
15	ezh2	11.5	ccnd1	26.2	Human	100.00	20132185
16	fos	24.8	ccnd1	26.2	Human	100.00	20188076
17	hdac1	11.3	ccnd1	26.2	Human	100.00	20049841
18	hdac1	11.3	ccnd1	26.2	Human	100.00	20821348
19	hif1a	21.7	ccnd1	26.2	Human	100.00	20179204
20	hoxb7	4.7	ccnd1	26.2	Human	100.00	21474578
21	jun	34.4	ccnd1	26.2	Human	100.00	10500157
22	jun	34.4	ccnd1	26.2	Human	100.00	21474819
23	jund	8.9	ccnd1	26.2	Human	100.00	20220142
24	kdm4b	2.7	ccnd1	26.2	Human	100.00	20682797
25	klf4	16.9	ccnd1	26.2	Human	100.00	21224073
26	klf5	6.7	ccnd1	26.2	Human	100.00	19189969
27	klf6	6.5	ccnd1	26.2	Human	100.00	18822210
28	lef1	5.2	ccnd1	26.2	Human	100.00	19620402
29	mirn1	14.7	ccnd1	26.2	Human	100.00	2
30	mirn106b	9.4	ccnd1	26.2	Human	100.00	1
31	mirn122	9.6	ccnd1	26.2	Mouse	100.00	2
32	mirn122	9.6	ccnd1	26.2	Mouse	100.00	2
33	mirn122	9.6	ccnd1	26.2	Mouse	100.00	2
34	mirn122	9.6	ccnd1	26.2	Mouse	100.00	2
35	mirn138	7	ccnd1	26.2	Human	100.00	1
36	mirn138	7	ccnd1	26.2	Mouse	100.00	1
37	mirn138	7	ccnd1	26.2	Mouse	100.00	1
38	mirn138	7	ccnd1	26.2	Mouse	100.00	1
39	mirn149	32	ccnd1	26.2	Human	-0.87	10
40	mirn155	20.6	ccnd1	26.2	Human	100.00	1
41	mirn15a	21.3	ccnd1	26.2	Human	100.00	3
42	mirn15a	21.3	ccnd1	26.2	Mouse	100.00	3
43	mirn15a	21.3	ccnd1	26.2	Mouse	100.00	3
44	mirn15b	11.4	ccnd1	26.2	Mouse	100.00	1
45	mirn15b	11.4	ccnd1	26.2	Mouse	100.00	1
46	mirn15b	11.4	ccnd1	26.2	Human	100.00	2
47	mirn16	18.6	ccnd1	26.2	Human	100.00	2
48	mirn16	18.6	ccnd1	26.2	Mouse	100.00	2
49	mirn16	18.6	ccnd1	26.2	Mouse	100.00	2
50	mirn16	18.6	ccnd1	26.2	Mouse	100.00	2
51	mirn17	20.6	ccnd1	26.2	Mouse	100.00	1
52	mirn17	20.6	ccnd1	26.2	Mouse	100.00	1
53	mirn17	20.6	ccnd1	26.2	Human	100.00	3
54	mirn183	7.2	ccnd1	26.2	Human	100.00	2
55	mirn193b	16.1	ccnd1	26.2	Human	100.00	3
56	mirn193b	16.1	ccnd1	26.2	Mouse	100.00	1
57	mirn193b	16.1	ccnd1	26.2	Mouse	100.00	1
58	mirn195	6.1	ccnd1	26.2	Human	100.00	2
59	mirn19a	6.3	ccnd1	26.2	Human	100.00	2
60	mirn204	9	ccnd1	26.2	Human	-0.12	3
61	mirn20a	12.1	ccnd1	26.2	Human	100.00	2
62	mirn20a	12.1	ccnd1	26.2	Mouse	100.00	1
63	mirn20a	12.1	ccnd1	26.2	Mouse	100.00	1
64	mirn27a	16.9	ccnd1	26.2	Human	100.00	1
65	mirn296	9.3	ccnd1	26.2	Human	100.00	1
66	mirn296	9.3	ccnd1	26.2	Mouse	0.03	3
67	mirn302a	1.7	ccnd1	26.2	Human	100.00	1
68	mirn338	2.3	ccnd1	26.2	Human	100.00	1
69	mirn34a	19.1	ccnd1	26.2	Mouse	100.00	1
70	mirn34a	19.1	ccnd1	26.2	Mouse	100.00	1
71	mirn34a	19.1	ccnd1	26.2	Mouse	100.00	1
72	mirn34a	19.1	ccnd1	26.2	Mouse	100.00	1
73	mirn34b	12.9	ccnd1	26.2	Mouse	100.00	1
74	mirn34b	12.9	ccnd1	26.2	Mouse	100.00	1
75	mirn374b	3.7	ccnd1	26.2	Human	100.00	2
76	mirn432	2.6	ccnd1	26.2	Human	0.54	3
77	mirn449a	6.1	ccnd1	26.2	Mouse	100.00	2
78	mirn449a	6.1	ccnd1	26.2	Mouse	100.00	2
79	mirn449a	6.1	ccnd1	26.2	Mouse	100.00	2
80	mirn449a	6.1	ccnd1	26.2	Mouse	100.00	2
81	mirn484	13.5	ccnd1	26.2	Human	-0.13	3
82	mirn499	1.2	ccnd1	26.2	Human	0.04	5
83	mirn503	7	ccnd1	26.2	Human	100.00	1
84	mirn520b	2.1	ccnd1	26.2	Human	100.00	2
85	mirn702	5.8	ccnd1	26.2	Mouse	-0.01	3
86	mirn9	18.4	ccnd1	26.2	Human	100.00	2
87	mirn9	18.4	ccnd1	26.2	Mouse	100.00	1
88	mirn92a	30.6	ccnd1	26.2	Human	100.00	1
89	mirn93	12.2	ccnd1	26.2	Human	100.00	2
90	mirnlet7b	24	ccnd1	26.2	Human	100.00	4
91	mirnlet7b	24	ccnd1	26.2	Mouse	100.00	3
92	mybl2	3.4	ccnd1	26.2	Human	100.00	15922873
93	myc	32.8	ccnd1	26.2	Human	100.00	14757441
94	nanog	2.6	ccnd1	26.2	Human	100.00	22381696
95	nfkb1	41.4	ccnd1	26.2	Human	100.00	18566231
96	nr3c1	15.3	ccnd1	26.2	Human	100.00	18097517
97	pgr	4.6	ccnd1	26.2	Human	100.00	22542550
98	pou2f1	4.8	ccnd1	26.2	Human	100.00	12391146
99	pparg	77.1	ccnd1	26.2	Human	100.00	14764597
100	rela	34.9	ccnd1	26.2	Human	100.00	10464245
101	rela	34.9	ccnd1	26.2	Human	100.00	18566231
102	runx3	7.9	ccnd1	26.2	Human	100.00	15930301
103	sirt1	16.5	ccnd1	26.2	Human	100.00	21474819
104	smarca4	4.4	ccnd1	26.2	Human	100.00	18239461
105	sox2	7.5	ccnd1	26.2	Human	100.00	18456656
106	sox2	7.5	ccnd1	26.2	Human		1
107	sox6	4.3	ccnd1	26.2	Human	100.00	21084391
108	sp1	40.7	ccnd1	26.2	Human	100.00	19755513
109	sp3	9.8	ccnd1	26.2	Human	100.00	22334592
110	stat3	34.7	ccnd1	26.2	Human	100.00	19880237
111	stat5a	12.6	ccnd1	26.2	Human	100.00	14645506
112	stat5b	6.9	ccnd1	26.2	Human	100.00	14645506
113	tcf4	10.8	ccnd1	26.2	Human	100.00	20459685
114	tp53	29.1	ccnd1	26.2	Human	100.00	12808109
115	tsc22d3	13.6	ccnd1	26.2	Human	100.00	19814803