Node

NCBI Gene

Symbol cdkn1a Gene ID 1026
IF 16.2% Link Number 1
Full Name cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Aliases CAP20,CDKN1,CIP1,MDA-6,P21,SDI1,WAF1,p21CIP1
Summary

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]

Node Expression

# PMID Condition Expression Material  
1 26484295 mice display late-onset obesity and hypersensitivity to a high-fat diet Up-Regulated mouse
2 11445576   adipo-enriched 3T3-L1

Relation Chart

Chart Legend

Relation Table (1 record)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 hdac6 3.5 inhibits cdkn1a 16.2 bind to DNA (IP)immunoprecipitation,Co-IP,Immunofluorescence,Overexpression and knockdown,Western blot 12391164

Prediction Chart

Chart Legend

Prediction Table (112 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 abl1 5.1 cdkn1a 16.2 Human 100.00 11753601
2 ar 22.7 cdkn1a 16.2 Human 100.00 10076995
3 ar 22.7 cdkn1a 16.2 Human 100.00 16281084
4 atf2 9.1 cdkn1a 16.2 Human 100.00 10506225
5 bcl6 12.9 cdkn1a 16.2 Human 100.00 16142238
6 brca1 29.8 cdkn1a 16.2 Human 100.00 21245169
7 brca1 29.8 cdkn1a 16.2 Human 100.00 21245169
8 brca1 29.8 cdkn1a 16.2 Human 100.00 21245169
9 cebpb 40.4 cdkn1a 16.2 Human 100.00 15041706
10 crebbp 6.4 cdkn1a 16.2 Human 100.00 15286705
11 e2f1 22.1 cdkn1a 16.2 Human 100.00 10030670
12 e2f3 5.4 cdkn1a 16.2 Human 100.00 10030670
13 egr1 21.1 cdkn1a 16.2 Human 100.00 12690110
14 ehmt2 2.4 cdkn1a 16.2 Human 100.00 16287849
15 ep300 11.4 cdkn1a 16.2 Human 100.00 21245169
16 ercc2 2.9 cdkn1a 16.2 Human 100.00 22387547
17 esr1 17.1 cdkn1a 16.2 Human 100.00 15378598
18 esr1 17.1 cdkn1a 16.2 Human 100.00 17681750
19 ets1 11.9 cdkn1a 16.2 Human 100.00 18955504
20 ets2 6 cdkn1a 16.2 Human 100.00 11114728
21 ezh2 11.5 cdkn1a 16.2 Human 100.00 21629038
22 foxg1 3.3 cdkn1a 16.2 Human 100.00 19755996
23 hdac1 11.3 cdkn1a 16.2 Human 100.00 19182791
24 hdac2 3.5 cdkn1a 16.2 Human 100.00 20190809
25 hdac4 9.2 cdkn1a 16.2 Human 100.00 18632985
26 hdac9 10.5 cdkn1a 16.2 Human 100.00 21084857
27 hipk2 6.7 cdkn1a 16.2 Human 100.00 15897882
28 hnf4a 8.6 cdkn1a 16.2 Human 100.00 17885207
29 irf1 10.6 cdkn1a 16.2 Human 100.00 12531694
30 irf9 2.5 cdkn1a 16.2 Human 100.00 15362048
31 jun 34.4 cdkn1a 16.2 Human 100.00 18094076
32 junb 7.2 cdkn1a 16.2 Human 100.00 10506225
33 jund 8.9 cdkn1a 16.2 Human 100.00 10506225
34 kat2b 7.9 cdkn1a 16.2 Human 100.00 19525977
35 klf16 3.7 cdkn1a 16.2 Human 100.00 16172401
36 klf2 11.7 cdkn1a 16.2 Human 100.00 15361832
37 klf4 16.9 cdkn1a 16.2 Human 100.00 19737957
38 klf4 16.9 cdkn1a 16.2 Human 100.00 21224073
39 klf6 6.5 cdkn1a 16.2 Human 100.00 18822210
40 mirn106a 7.6 cdkn1a 16.2 Human 100.00 3
41 mirn106b 9.4 cdkn1a 16.2 Human 100.00 3
42 mirn132 6.8 cdkn1a 16.2 Human 100.00 1
43 mirn17 20.6 cdkn1a 16.2 Human 100.00 4
44 mirn208 0.5 cdkn1a 16.2 Human 100.00 1
45 mirn20a 12.1 cdkn1a 16.2 Human 100.00 3
46 mirn20b 4.9 cdkn1a 16.2 Human 100.00 2
47 mirn22 15.2 cdkn1a 16.2 Human 100.00 1
48 mirn224 4.8 cdkn1a 16.2 Human 100.00 1
49 mirn28 2.4 cdkn1a 16.2 Human 100.00 1
50 mirn296 9.3 cdkn1a 16.2 Human 100.00 1
51 mirn299 2.5 cdkn1a 16.2 Human 100.00 1
52 mirn299 2.5 cdkn1a 16.2 Human 100.00 1
53 mirn335 19 cdkn1a 16.2 Human 100.00 2
54 mirn345 3.5 cdkn1a 16.2 Human 100.00 1
55 mirn345 3.5 cdkn1a 16.2 Mouse -0.06 3
56 mirn423 10.6 cdkn1a 16.2 Human 100.00 2
57 mirn520h 2.1 cdkn1a 16.2 Human 100.00 1
58 mirn639 1.7 cdkn1a 16.2 Human 100.00 1
59 mirn663a 5.1 cdkn1a 16.2 Human 100.00 1
60 mirn93 12.2 cdkn1a 16.2 Human 100.00 3
61 mirn98 20.1 cdkn1a 16.2 Human 100.00 1
62 mirn98 20.1 cdkn1a 16.2 Human 100.00 1
63 mirnlet7a 11.5 cdkn1a 16.2 Human 100.00 1
64 mirnlet7f 4.2 cdkn1a 16.2 Human 100.00 2
65 mta1 4.1 cdkn1a 16.2 Human 100.00 20071335
66 myc 32.8 cdkn1a 16.2 Human 100.00 16738884
67 myc 32.8 cdkn1a 16.2 Human 100.00 12553001
68 myf5 1.1 cdkn1a 16.2 Human 100.00 12105204
69 myf6 0.4 cdkn1a 16.2 Human 100.00 12105204
70 myod1 6 cdkn1a 16.2 Human 100.00 12105204
71 myog 2.6 cdkn1a 16.2 Human 100.00 12105204
72 ncoa1 4.9 cdkn1a 16.2 Human 100.00 15286705
73 nfix 4.3 cdkn1a 16.2 Human 100.00 17130157
74 nfkb1 41.4 cdkn1a 16.2 Human 100.00 18954936
75 nr3c1 15.3 cdkn1a 16.2 Human 100.00 17989362
76 nupr1 4.4 cdkn1a 16.2 Human 100.00 18690848
77 parp1 5.5 cdkn1a 16.2 Human 100.00 20711239
78 pou5f1 5.4 cdkn1a 16.2 Human 100.00 19968627
79 pparg 77.1 cdkn1a 16.2 Human 100.00 15041706
80 ptma 1.7 cdkn1a 16.2 Human 100.00 16540664
81 rara 11.3 cdkn1a 16.2 Human 100.00 10356361
82 rb1 15.2 cdkn1a 16.2 Human 100.00 14527674
83 rb1 15.2 cdkn1a 16.2 Human 100.00 9671466
84 rel 3.4 cdkn1a 16.2 Human 100.00 15566959
85 rela 34.9 cdkn1a 16.2 Human 100.00 18269916
86 rela 34.9 cdkn1a 16.2 Human 100.00 18954936
87 runx3 7.9 cdkn1a 16.2 Human 100.00 20599712
88 sirt1 16.5 cdkn1a 16.2 Human 100.00 21719763
89 sirt2 2.2 cdkn1a 16.2 Human 100.00 14522900
90 smad2 5.1 cdkn1a 16.2 Human 100.00 10506225
91 smad3 13.4 cdkn1a 16.2 Human 100.00 10878024
92 smad4 10.4 cdkn1a 16.2 Human 100.00 10878024
93 smad7 7.3 cdkn1a 16.2 Human 100.00 15555279
94 smarca4 4.4 cdkn1a 16.2 Human 100.00 14729964
95 sox6 4.3 cdkn1a 16.2 Human 100.00 21084391
96 sox9 9.6 cdkn1a 16.2 Human 100.00 19273910
97 sox9 9.6 cdkn1a 16.2 Human 100.00 20651055
98 sp1 40.7 cdkn1a 16.2 Human 100.00 12773551
99 sp3 9.8 cdkn1a 16.2 Human 100.00 12434298
100 sp3 9.8 cdkn1a 16.2 Human 100.00 12773551
101 stat1 16.4 cdkn1a 16.2 Human 100.00 10023678
102 stat3 34.7 cdkn1a 16.2 Human 100.00 10023678
103 tbx3 2.2 cdkn1a 16.2 Human 100.00 20624445
104 tcf3 5.7 cdkn1a 16.2 Human 100.00 15856770
105 tfap2a 12.1 cdkn1a 16.2 Human 100.00 20805990
106 tfap2a 12.1 cdkn1a 16.2 Human 100.00 11420667
107 tfap4 4.8 cdkn1a 16.2 Human 100.00 19270520
108 tp53 29.1 cdkn1a 16.2 Human 100.00 10327058
109 tp53 29.1 cdkn1a 16.2 Human 100.00 17344317
110 tp63 3.9 cdkn1a 16.2 Human 100.00 16007146
111 tsc22d3 13.6 cdkn1a 16.2 Human 100.00 19814803
112 zfhx3 5 cdkn1a 16.2 Human 100.00 14978340