Node
NCBI Gene
| Symbol | cxcl3 | Gene ID | 2921 |
| IF | 0.9% | Link Number | 1 |
| Full Name | C-X-C motif chemokine ligand 3 | ||
| Aliases | CINC-2b,GRO3,GROg,MIP-2b,MIP2B,SCYB3 | ||
| Summary | This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014] |
||
Node Summary
PMID: 27512010
CXCL3 Positively Regulates Adipogenic Differentiation. CXCL3 treatment of 3T3-L1 cells significantly induced the phosphorylation of ERK and JNK. Furthermore, CXCL3-induced C/EBPβ and δ expression was suppressed by both ERK and JNK-specific inhibitors. Furthermore, Chromatin immunoprecipitation assay revealed functional binding of PPARγ2 within cxcl3 promoter region.
Node Expression
| # | PMID | Condition | Expression | Material | |
|---|---|---|---|---|---|
| 1 | 26111340 | hMSC Low Density & DMI-Induced High expression | Up-Regulated | MSC |
Relation Chart
Chart Legend
Relation Table (1 record)
Prediction Chart
Chart Legend
Prediction Table (0 record)
| # | Source | IF(%) | Target | IF(%) | Species | Agreement | Computational Predictions / PMID |
|---|---|---|---|---|---|---|---|
Sorry, no matching records found. |
|||||||
