Node

NCBI Gene

Symbol e2f1 Gene ID 1869
IF 22.1% Link Number 2
Full Name E2F transcription factor 1
Aliases E2F-1,RBAP1,RBBP3,RBP3
Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

Node Summary

PMID: 11463572

Inactivation of Rb2/p130 by phosphorylation enables clonal expansion. When cells exit the cell cycle, E2F loses its activity and terminal differentiation is initiated.

PMID: 18650841

During the cell cycle, clonal expansion is regulated by the Rb-E2F pathway, which is responsible for the G1-to-S transition. Rb inhibits the cell cycle by binding to, and repressing, the transcriptional activity of E2F.Upon hyperphosphorylation of Rb by cyclin-dependent kinases, E3F is released and promotes transcriptional activation of genes that encode cell-cycle regulators required for S phase entry; a process that initiates clonal expansion.

Node Expression

# PMID Condition Expression Material  
1 27108396 Control VS hADSC day 7 post-adipogenic induction (1 -1.31) hADSC
2 27108396 Control VS hADSC day 1 post-adipogenic induction (1 -1.36) hADSC
3 27044590 group(MSC AD14day) (0 -1.8400276006444) hMSC
4 15051823 2 5 Up(1 1.6)fold 3T3-L1
5 12631704 osteogenic TF(1 2 7) 1 1 2 MSC

Relation Chart

Chart Legend

Relation Table (2 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 e2f1 22.1 activates prb 3.8 bind to protein This article has been retracted. 19633359
2 pRb 0 inhibits e2f1 22.1 bind to DNA 5′-RACE,Bioinformatic,ChIP,Microarray,Overexpression and knockdown,RT-qPCR or RT-PCR 18650841

Prediction Chart

Chart Legend

Prediction Table (139 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 e2f1 22.1 tp53 29.1 Human 100.00 15706352
2 e2f1 22.1 tp53 29.1 Human 100.00 8557038
3 e2f1 22.1 irf3 4.3 Human 100.00 21225257
4 e2f1 22.1 abcb1 4 Human 100.00 23542036
5 e2f1 22.1 ar 22.7 Human 100.00 21099103
6 e2f1 22.1 asf1b 2.1 Human 100.00 17328667
7 e2f1 22.1 bcl2 14 Human 100.00 11559537
8 e2f1 22.1 birc5 9.5 Human 100.00 17848598
9 e2f1 22.1 birc5 9.5 Human 100.00 19102934
10 e2f1 22.1 brca1 29.8 Human 100.00 20068145
11 e2f1 22.1 ccnb1 10.2 Human 100.00 22508987
12 e2f1 22.1 ccnd1 26.2 Human 100.00 20655656
13 e2f1 22.1 ccne1 6 Human 100.00 14618416
14 e2f1 22.1 cdk1 5.2 Human 100.00 14618416
15 e2f1 22.1 cdkn1a 16.2 Human 100.00 10030670
16 e2f1 22.1 cdkn2a 8.6 Human 100.00 11705881
17 e2f1 22.1 crebbp 6.4 Human 100.00 9238849
18 e2f1 22.1 ctnnbip1 2.5 Human 100.00 21532622
19 e2f1 22.1 ddit3 15.1 Human 100.00 20971808
20 e2f1 22.1 dhfr 3.5 Human 100.00 14618416
21 e2f1 22.1 dok1 4.6 Human 100.00 23028047
22 e2f1 22.1 dusp1 10.7 Human 100.00 17638884
23 e2f1 22.1 e2f1 22.1 Human 100.00 7958836
24 e2f1 22.1 ect2 5.4 Human 100.00 21886810
25 e2f1 22.1 fgfr1 6.9 Human 100.00 19303924
26 e2f1 22.1 hmga1 10.3 Human 100.00 22389255
27 e2f1 22.1 il1b 10 Human 100.00 17707233
28 e2f1 22.1 irf3 4.3 Human 100.00 21225257
29 e2f1 22.1 isyna1 2.7 Human 100.00 15464731
30 e2f1 22.1 mapk8 3.6 Human 100.00 20800677
31 e2f1 22.1 mcl1 2.9 Human 100.00 11705881
32 e2f1 22.1 mcm5 4.2 Human 100.00 17210690
33 e2f1 22.1 mdm2 4.2 Human 100.00 20837136
34 e2f1 22.1 mt1g 4.7 Human 100.00 15735762
35 e2f1 22.1 myb 11.6 Human 100.00 8137237
36 e2f1 22.1 mybl2 3.4 Human 100.00 14618416
37 e2f1 22.1 myc 32.8 Human 100.00 11705881
38 e2f1 22.1 nrip1 5.6 Human 100.00 22629304
39 e2f1 22.1 pcna 5.1 Human 100.00 14618416
40 e2f1 22.1 pdk4 7.6 Human 100.00 21625432
41 e2f1 22.1 peg10 4.8 Human 100.00 18625225
42 e2f1 22.1 pin1 3.1 Human 100.00 20376080
43 e2f1 22.1 pola1 3.4 Human 100.00 9649317
44 e2f1 22.1 rb1 15.2 Human 100.00 8264596
45 e2f1 22.1 rrm1 5 Human 100.00 14618416
46 e2f1 22.1 rrm2 8.2 Human 100.00 19416980
47 e2f1 22.1 serpine1 15.7 Human 100.00 11402043
48 e2f1 22.1 tert 5.4 Human 100.00 21411498
49 e2f1 22.1 tert 5.4 Human 100.00 21411498
50 e2f1 22.1 thbs1 11.5 Human 100.00 20976175
51 e2f1 22.1 tk1 5.4 Human 100.00 8114719
52 e2f1 22.1 tlr3 3.4 Human 100.00 22310660
53 e2f1 22.1 tnf 18.8 Human 100.00 17707233
54 e2f1 22.1 tnfsf11 3.1 Human 100.00 18381203
55 e2f1 22.1 top2a 2.7 Human 100.00 11313881
56 e2f1 22.1 tp53 29.1 Human 100.00 15706352
57 e2f1 22.1 tp53 29.1 Human 100.00 8557038
58 e2f1 22.1 tyms 5.5 Human 100.00 14618416
59 e2f1 22.1 vegfa 16.5 Human 100.00 16835303
60 e2f1 22.1 e2f1 22.1 Human 100.00 7958836
61 e2f1 22.1 acot7 2.2 Human   1
62 e2f1 22.1 agtrap 3.4 Human   1
63 e2f1 22.1 atad3a 2.1 Human   1
64 e2f1 22.1 capzb 3.1 Human   1
65 e2f1 22.1 ccne1 6 Human   1
66 e2f1 22.1 cdk1 5.2 Human   1
67 e2f1 22.1 clic4 4.8 Human   1
68 e2f1 22.1 e2f1 22.1 Human   1
69 e2f1 22.1 errfi1 3.8 Human   1
70 e2f1 22.1 h6pd 5.4 Human   1
71 e2f1 22.1 hes4 1 Human   1
72 e2f1 22.1 kdm1a 1.3 Human   1
73 e2f1 22.1 map3k6 2.4 Human   1
74 e2f1 22.1 mirn200b 5.6 Human   1
75 e2f1 22.1 myb 11.6 Human   1
76 e2f1 22.1 pax7 1 Human   1
77 e2f1 22.1 pdpn 3.1 Human   1
78 e2f1 22.1 pex14 2.1 Human   1
79 e2f1 22.1 prdm16 7.7 Human   1
80 e2f1 22.1 rb1 15.2 Human   1
81 e2f1 22.1 rere 2.4 Human   1
82 e2f1 22.1 stx12 1.6 Human   1
83 e2f1 22.1 wdtc1 3.6 Human   1
84 e2f1 22.1 pparg 77.1 Human 100.00 20971808
85 e2f1 22.1 brca1 29.8 Human 100.00 20068145
86 e2f1 22.1 brca1 29.8 Human 100.00 20068145
87 e2f1 22.1 ar 22.7 Human 100.00 21099103
88 e2f1 22.1 myc 32.8 Human 100.00 11705881
89 e2f1 22.1 bcl2 14 Human 100.00 11559537
90 e2f1 22.1 brca1 29.8 Human 100.00 20068145
91 e2f1 22.1 tert 5.4 Human 100.00 21411498
92 e2f1 22.1 tert 5.4 Human 100.00 21411498
93 e2f1 22.1 ccl3 1.8 Human 100.00 17707233
94 e2f1 22.1 etv4 4.2 Human 100.00 18687701
95 e2f1 22.1 hspa5 4.8 Human 100.00 18840615
96 e2f1 22.1 kir3dl1 0.9 Human 100.00 18358829
97 e2f1 22.1 uhrf1 2.2 Human 100.00 12838312
98 esr1 17.1 e2f1 22.1 Human 100.00 10446910
99 hcfc1 3.3 e2f1 22.1 Human 100.00 19763085
100 hes1 4.6 e2f1 22.1 Human 100.00 15467735
101 irf1 10.6 e2f1 22.1 Human 100.00 22200613
102 kat2b 7.9 e2f1 22.1 Human 100.00 20530585
103 mirn106a 7.6 e2f1 22.1 Mouse 100.00 1
104 mirn106a 7.6 e2f1 22.1 Mouse 100.00 1
105 mirn106a 7.6 e2f1 22.1 Mouse 100.00 1
106 mirn106b 9.4 e2f1 22.1 Mouse 100.00 1
107 mirn106b 9.4 e2f1 22.1 Mouse 100.00 1
108 mirn205 5.5 e2f1 22.1 Mouse 100.00 1
109 mirn223 8.6 e2f1 22.1 Mouse 100.00 1
110 mirn223 8.6 e2f1 22.1 Mouse 100.00 1
111 mirn331 8.2 e2f1 22.1 Mouse 100.00 1
112 mirn331 8.2 e2f1 22.1 Mouse 100.00 1
113 mirn362 5.6 e2f1 22.1 Mouse 100.00 1
114 mirn362 5.6 e2f1 22.1 Mouse 100.00 1
115 mirn466a 11.6 e2f1 22.1 Mouse 1.48 3
116 mirn466b 4.7 e2f1 22.1 Mouse 1.41 3
117 mirn466c 5.5 e2f1 22.1 Mouse 1.41 3
118 mirn466d 10.1 e2f1 22.1 Mouse 1.41 3
119 mirn669b 4.7 e2f1 22.1 Mouse 1.44 3
120 mirn669c 10.2 e2f1 22.1 Mouse 1.68 4
121 mirn93 12.2 e2f1 22.1 Mouse 100.00 1
122 mirn93 12.2 e2f1 22.1 Mouse 100.00 1
123 ndn 2.9 e2f1 22.1 Human 100.00 9422723
124 nfkb1 41.4 e2f1 22.1 Human 100.00 16725311
125 nfkb1 41.4 e2f1 22.1 Human 100.00 16725311
126 nr0b2 6 e2f1 22.1 Human 100.00 18657049
127 nr0b2 6 e2f1 22.1 Human 100.00 18657049
128 nr2f2 6.2 e2f1 22.1 Human 100.00 22734039
129 nr2f2 6.2 e2f1 22.1 Human 100.00 22734039
130 nr4a1 8.1 e2f1 22.1 Human 100.00 12947120
131 parp1 5.5 e2f1 22.1 Human 100.00 14627987
132 pgr 4.6 e2f1 22.1 Human 100.00 20123965
133 rb1 15.2 e2f1 22.1 Human 100.00 12460790
134 rela 34.9 e2f1 22.1 Human 100.00 16725311
135 rela 34.9 e2f1 22.1 Human 100.00 16725311
136 sp1 40.7 e2f1 22.1 Human 100.00 10446910
137 tp53 29.1 e2f1 22.1 Human 100.00 8557038
138 tp53 29.1 e2f1 22.1 Human 100.00 8557038
139 ybx1 4.4 e2f1 22.1 Human 100.00 22205655