Node

NCBI Gene

Symbol egr1 Gene ID 1958
IF 21.1% Link Number 3
Full Name early growth response 1
Aliases AT225,G0S30,KROX-24,NGFI-A,TIS8,ZIF-268,ZNF225
Summary

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

Node Summary

PMID: 19229250

Inhibits preadipocyte differentiation and decreases adipocyte insulin sensitivity (via PI3K/Akt and Erk/MAPK signaling)

Node Expression

# PMID Condition Expression Material  
1 23894377 control VS cold-induced WAT (1 2) (1 5.3125343) mouse
2 24130839 porcine intramuscular/subcutaneous adipocyte-dif(0 2 4)day (3.6 0.7 1.2) IMF
3 23967297 HFD-adi(6 14) HFD-ageMadi(1 -9.0) mouse
4 23967297 14M HFD(1 2) HFD-Madi(1 -3.5) mouse
5 23967297 6M HFD(1 2) HFD-Madi(1 2.8) mouse
6 15033539 dif(0 2 8 16 24 48 96)h dif(1 2 -10 -11 -11 -12 -13)fold 3T3-L1
7 12631704 chondrogenic TF(0 1 2 7)d fold(1 -3 -3 -3) MSC
8 12631704 osteogenic TF(0 1 2 7)d fold(1 -3 -3 -3) MSC
9 12631704 osteogenic TF(1 2 7) 1 1 2 MSC

Relation Chart

Chart Legend

Relation Table (3 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 egr1 21.1 activates cebpb 40.4 bind to protein (IP)immunoprecipitation,ChIP,Co-IP,EMSA,Phosphorylation,Reporter,Western blot 12947119,25535333
2 egr1 21.1 activates ldlr 12.1 bind to DNA (IP)immunoprecipitation,ChIP,Co-IP,EMSA,Phosphorylation,Reporter,Western blot 12947119
3 egr1 21.1 inhibits mirn133 4 signal transduction   24287695

Prediction Chart

Chart Legend

Prediction Table (111 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 atf5 1.9 egr1 21.1 Human 100.00 19531563
2 brca1 29.8 egr1 21.1 Human 100.00 20103632
3 brca1 29.8 egr1 21.1 Human 100.00 20103632
4 brca1 29.8 egr1 21.1 Human 100.00 20103632
5 brca1 29.8 egr1 21.1 Human 100.00 20103632
6 crebbp 6.4 egr1 21.1 Human 100.00 9806899
7 egr1 21.1 tnfsf10 4.4 Human 100.00 17932312
8 egr1 21.1 ep300 11.4 Human 100.00 18798221
9 egr1 21.1 ar 22.7 Human 100.00 15517885
10 egr1 21.1 hif1a 21.7 Human 100.00 18506761
11 egr1 21.1 id3 7 Human 100.00 17922653
12 egr1 21.1 tp53 29.1 Human 100.00 9242687
13 egr1 21.1 atf3 13 Human 100.00 21205742
14 egr1 21.1 abl1 5.1 Human   1
15 egr1 21.1 bmp7 3.6 Human   1
16 egr1 21.1 cbfb 5.6 Human   1
17 egr1 21.1 clic4 4.8 Human   1
18 egr1 21.1 col18a1 4.4 Human   1
19 egr1 21.1 pparg 77.1 Human 100.00 12011097
20 egr1 21.1 fat3 2.2 Human   1
21 egr1 21.1 gata2 4.9 Human   1
22 egr1 21.1 hadhb 6.3 Human   1
23 egr1 21.1 klf11 4.3 Human   1
24 egr1 21.1 klf3 5.2 Human   1
25 egr1 21.1 maf 3.1 Human   1
26 egr1 21.1 mapk1 10.5 Human   1
27 egr1 21.1 me1 6.1 Human   1
28 egr1 21.1 mtdh 1.8 Human   1
29 egr1 21.1 nab1 1.2 Human   1
30 egr1 21.1 phf2 3.1 Human   1
31 egr1 21.1 phldb1 1.5 Human   1
32 egr1 21.1 pi4ka 1.4 Human   1
33 egr1 21.1 pid1 4.6 Human   1
34 egr1 21.1 pmf1 1.7 Human   1
35 egr1 21.1 rora 4.3 Human   1
36 egr1 21.1 scarb1 4.4 Human   1
37 egr1 21.1 slc19a1 2.1 Human   1
38 egr1 21.1 sp3 9.8 Human   1
39 egr1 21.1 taldo1 3.8 Human   1
40 egr1 21.1 tram2 2 Human   1
41 egr1 21.1 tcf4 10.8 Human 100.00 18798221
42 egr1 21.1 abcb1 4 Human 100.00 7565762
43 egr1 21.1 akr1b1 1.4 Human 100.00 12890669
44 egr1 21.1 ar 22.7 Human 100.00 15517885
45 egr1 21.1 atf3 13 Human 100.00 21205742
46 egr1 21.1 bcar1 4.1 Human 100.00 22431919
47 egr1 21.1 ccnd1 26.2 Human 100.00 11502738
48 egr1 21.1 ccnd2 13.3 Human 100.00 20590664
49 egr1 21.1 cdkn1a 16.2 Human 100.00 12690110
50 egr1 21.1 cxcl8 3.8 Human 100.00 15517885
51 egr1 21.1 egfr 12.4 Human 100.00 11830539
52 egr1 21.1 ep300 11.4 Human 100.00 18798221
53 egr1 21.1 f3 5.8 Human 100.00 10707957
54 egr1 21.1 fas 10.3 Human 100.00 9300687
55 egr1 21.1 faslg 3 Human 100.00 14563113
56 egr1 21.1 fgf2 9.4 Human 100.00 8702507
57 egr1 21.1 fn1 18 Human 100.00 15608673
58 egr1 21.1 gdf15 7.3 Human 100.00 17715378
59 egr1 21.1 hif1a 21.7 Human 100.00 18506761
60 egr1 21.1 hsd11b2 1.4 Human 100.00 15659537
61 egr1 21.1 id3 7 Human 100.00 17922653
62 egr1 21.1 ifng 5.6 Human 100.00 8900159
63 egr1 21.1 igf2 8.1 Human 100.00 8634146
64 egr1 21.1 il2 3.8 Human 100.00 12560487
65 egr1 21.1 il6 26.3 Human 100.00 15517885
66 egr1 21.1 ldlr 12.1 Human 100.00 12235180
67 egr1 21.1 mmp14 6.5 Human 100.00 17158885
68 egr1 21.1 myb 11.6 Human 100.00 7559553
69 egr1 21.1 nfkb1 41.4 Human 100.00 10671503
70 egr1 21.1 pdgfb 2 Human 100.00 16092976
71 egr1 21.1 plau 12 Human 100.00 21283769
72 egr1 21.1 por 4.8 Human 100.00 10864447
73 egr1 21.1 psen2 6.3 Human 100.00 14585504
74 egr1 21.1 pten 14.7 Human 100.00 17516844
75 egr1 21.1 ptges 4.4 Human 100.00 21983014
76 egr1 21.1 ptgs2 17.4 Human 100.00 15517885
77 egr1 21.1 rbl2 4.3 Human 100.00 22431919
78 egr1 21.1 spry1 5.3 Human 100.00 21826097
79 egr1 21.1 stmn1 5.4 Human 100.00 19786090
80 egr1 21.1 tcf4 10.8 Human 100.00 18798221
81 egr1 21.1 tgfbr2 8.6 Human 100.00 10982796
82 egr1 21.1 tnf 18.8 Human 100.00 10913190
83 egr1 21.1 tp53 29.1 Human 100.00 9242687
84 egr1 21.1 vegfa 16.5 Human 100.00 20489156
85 egr1 21.1 vegfa 16.5 Human 100.00 15517885
86 egr1 21.1 wnt4 2.5 Human 100.00 18281035
87 ep300 11.4 egr1 21.1 Human 100.00 9806899
88 ets1 11.9 egr1 21.1 Human 100.00 19074849
89 ets1 11.9 egr1 21.1 Human 100.00 19074849
90 ets2 6 egr1 21.1 Human 100.00 9207063
91 foxo1 17.2 egr1 21.1 Human 100.00 22865884
92 foxo1 17.2 egr1 21.1 Human 100.00 22865884
93 hdac1 11.3 egr1 21.1 Human 100.00 21983014
94 klf5 6.7 egr1 21.1 Human 100.00 15098654
95 klf5 6.7 egr1 21.1 Human 100.00 15098654
96 mirn183 7.2 egr1 21.1 Mouse 100.00 1
97 mirn346 11.6 egr1 21.1 Mouse -0.07 3
98 mirn7045 3.3 egr1 21.1 Mouse -0.14 4
99 mirn92b 5.2 egr1 21.1 Mouse -0.08 3
100 nfkb1 41.4 egr1 21.1 Human 100.00 21983014
101 nfkb1 41.4 egr1 21.1 Human 100.00 21983014
102 rbmx 2.7 egr1 21.1 Human 100.00 16707624
103 rela 34.9 egr1 21.1 Human 100.00 21983014
104 rela 34.9 egr1 21.1 Human 100.00 21983014
105 sp1 40.7 egr1 21.1 Human 100.00 8349585
106 srf 6.6 egr1 21.1 Human   1
107 stat1 16.4 egr1 21.1 Human 100.00 16951379
108 stat1 16.4 egr1 21.1 Human 100.00 16951379
109 stat6 6.3 egr1 21.1 Human 100.00 16951379
110 tp53 29.1 egr1 21.1 Human 100.00 16990849
111 tp53 29.1 egr1 21.1 Human 100.00 16990849