Node

NCBI Gene

Symbol fabp4 Gene ID 2167
IF 33.1% Link Number 12
Full Name fatty acid binding protein 4, adipocyte
Aliases A-FABP,AFABP,ALBP,HEL-S-104,aP2
Summary

FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

Node Summary

PMID: 8664544

aP2 is the major lipid-binding protein in adipose cells,

Node Expression

# PMID Condition Expression Material  
1 27385551 human preadipocyte dif (0 384) hours (0 10.3641) preadipocyte
2 27385551 human preadipocyte dif (0 96) hours (0 10.3385) preadipocyte
3 27385551 human preadipocyte dif (0 192) hours (0 10.2956) preadipocyte
4 27385551 human preadipocyte dif (0 48) hours (0 9.6648) preadipocyte
5 27385551 human preadipocyte dif (6 48) hours (0 9.05624) preadipocyte
6 27108396 Control VS hADSC day 21 post-adipogenic induction (1 560.05) hADSC
7 27108396 Control VS hADSC day 14 post-adipogenic induction (1 659.49) hADSC
8 27108396 Control VS hADSC day 7 post-adipogenic induction (1 268.78) hADSC
9 27044590 group(MSC AD14day) (0 5.90515463084659) hMSC
10 25982065 hMSC LMNA 232 mutation Muscle dif (1 2) (0 3) MSC
11 20573458 subcutaneous,intramuscular adipocytes (1 2) (7.88 0) IMF
12 26205789 hADSC adipo-dif(7 21)day (1 0.298844667) ADSC
13 20952530 Subcutaneous VS Intramuscular fat (1 2) (18.5 17.3) IMF
14 17276354 dif time (-6 0 6 12 24 48 72 96 168) hour Relative exp (0.05 0 0 0 0.03 0.7 0.9 0.92 1)  
15 24845505   dif early stage up Cancer
16 23967297 age-Eadi(6 14 18)M age-adi(1 -1.2 -1.3) mouse
17 23967297 age-Badi(6 14 18) age-adi(1 -1.5 -2.6) mouse
18 23967297 age(6 14 18)M age-Eadi(1 -1.2 -1.3) mouse
19 23967297 age(6 14 18)M age-Madi(1 -1.52 -2.46) mouse
20 23967297 E-adi(6 14 24)M dif-age(1 -1.23 -1.32) mouse
21 23967297 B-adi(6 14 18) dif-age(1 -1.54 -2.57) mouse
22 23967297 age(6 14 18)M (-23.2 -27.0 -41.3) mouse
23 23296809 hIMF-TAG correlate IMF
24 21943323 adipogenic signal pathway-adi dif Up-regulated MSC
25 21943323 adipogenic(0 1 3 7 17 27) dif(-1.2 -0.8 -0.4 0 1 1.5) MSC
26 21772852 adipogenic DNA methylation MSC
27 19300518 PPARg-RXR target fold(15)/IgG 3T3-L1
28 19123974 (high-low)-marbled Hanwoo steers t-values(16.05) IMF
29 19123974 (high-low)-marbled Hanwoo steers fat(P<0.005),age(P<0.001) IMF
30 18820161 time(3 7 12)W*H/P*H ratio(1.20 2.33 1.53) IMF
31 18820161 time(3 7 12 20 25 30)M-P*H/RPLP0 ratio(0.02 0.07 0.03 0.08 0.08 0.2) IMF
32 18820161 time(3 7 12 20 25 30)M-W*H/RPLP0 ratio(0.02 0.03 0.04 0.1 0.08 0.06) IMF
33 18820161 time(3 7 12 20 25 30)M-W*H,gene-intramuscular fat correlations ratio(−0.29 −0.09 0.20 0.95 0.83 0.63) IMF
34 18820161 time(3 7 12 20 25 30)M-P*H,gene-intramuscular fat correlations ratio(0.04 −0.13 0.17 0.21 0.14 −0.57) IMF
35 18637193 adipogenic(2 10 15)d dif(5 6 8) ADSC
36 18489901 PPARg target Upregulated NIH-3T3
37 17697390 time(60 135 195 270) P/W ratio(1.32 0.56 0.14 0.20) IMF
38 15895078 IRS1-KO VS Control(1 2) Down(1 0.5)fold brown preadipocyte
39 15051823 2 5 Up(1 8)fold 3T3-L1
40 15033539 dif(0 2 8 16 24 48 96)h dif(1 1 4 5 5 12 16)fold 3T3-L1
41 14969395 dif(-1 7 14 21) fold(1 1063 1497 1457) MSC
42 12646203 dif(0 1 3 5 7 9 14) fold(1 1 1.5 1 3 4 3) MSC
43 12459256 1 3 4 5 7 8 9 0 2 4 3 2 4 3 3T3-L1
44 12021175 Ratio(1 2 3 4 5)preadi/fibro,TZD-preadi/preadi,adi/fibro,adi/preadi,TZD-adi/adi ratio(0 0 1 1 1） 3T3-L1
45 11445576   adipo-enriched 3T3-L1

Relation Chart

Chart Legend

Relation Table (12 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 aebp1 2.9 activates fabp4 33.1 others Bioinformatic,cell assay,ChIP-seq,Microarray,Overexpression and knockdown,Reporter 22723309
2 asxl1 6.9 inhibits fabp4 33.1 bind to DNA (IP)immunoprecipitation,Cell culture and differentiation,ChIP,Co-IP,Microarray,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 21047783
3 asxl2 1.6 inhibits fabp4 33.1 bind to DNA (IP)immunoprecipitation,Cell culture and differentiation,ChIP,Co-IP,Microarray,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 21047783
4 asxl2 1.6 activates fabp4 33.1 bind to DNA (IP)immunoprecipitation,Cell culture and differentiation,ChIP,Co-IP,Microarray,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 21047783
5 cebpa 40.7 activates fabp4 33.1 bind to DNA DNase footprinting assay,Reporter 2606350
6 dex 0.8 activates fabp4 33.1 others Cell culture and differentiation,RT-qPCR or RT-PCR 1753216
7 fatty acids 0.5 activates fabp4 33.1 others Cell culture and differentiation,RT-qPCR or RT-PCR 1753215
8 fos 24.8 activates fabp4 33.1 bind to DNA Review 22952395
9 igf1 20.1 activates fabp4 33.1 others Cell culture and differentiation,RT-qPCR or RT-PCR 1701639
10 klf3 5.2 inhibits fabp4 33.1 bind to DNA Mutagenesis,Overexpression and knockdown,RT-qPCR or RT-PCR 25036958
11 mirn24 17.5 inhibits fabp4 33.1 others Cell culture and differentiation,Microarray,Overexpression and knockdown,RT-qPCR or RT-PCR 24301787
12 pparg 77.1 activates fabp4 33.1 bind to DNA cell assay,Cell culture and differentiation,ELISA,Overexpression and knockdown,Reporter,RT-qPCR or RT-PCR,Triacylglycerol (TAG) Measurement,Western blot 20693579

Prediction Chart

Chart Legend

Prediction Table (5 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 asxl1 6.9 fabp4 33.1 Human 100.00 21047783
2 foxo1 17.2 fabp4 33.1 Human 100.00 20102700
3 ppara 15 fabp4 33.1 Human 100.00 19717768
4 pparg 77.1 fabp4 33.1 Human 100.00 21459326
5 tle3 3.6 fabp4 33.1 Human 100.00 21459326