Node

NCBI Gene

Symbol fas Gene ID 355
IF 10.3% Link Number 5
Full Name Fas cell surface death receptor
Aliases ALPS1A,APO-1,APT1,CD951,FASTM,TNFRSF6,FAS
Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

Node Expression

# PMID Condition Expression Material  
1 18820161 time(3 7 12 20 25 30)M-P*H/RPLP0 ratio(0.02 0.08 0.18 0.1 0.44 0.28) IMF
2 18820161 time(3 7 12 20 25 30)M-W*H/RPLP0 ratio(0.02 0.03 0.03 0.06 0.2 0.08) IMF
3 18820161 time(3 7 12 20 25 30)M-P*H,gene-intramuscular fat correlations ratio(0.92 0.60 0.35 0.34 0.18 0.71) IMF
4 18820161 time(3 7 12 20 25 30)M-W*H,gene-intramuscular fat correlations ratio(−0.73 0.23 −0.29 0.94 0.83 0.55) IMF
5 12646203 dif(0 1 3 5 7 9 14) fold(1 1 1.5 1 3 4 3) MSC
6 12138207 2 5 1 4 3T3-L1

Relation Chart

Chart Legend

Relation Table (5 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 creb1 23.9 activates fas 10.3 others Cell culture and differentiation,Overexpression and knockdown,Western blot 11375992
2 igf1 20.1 activates fas 10.3 others Overexpression and knockdown 7511375
3 mirn23a 11.6 inhibits fas 10.3 bind to RNA Overexpression and knockdown,Reporter 23804233
4 pparg 77.1 activates fas 10.3 bind to DNA Ligand-binding assay,Overexpression and knockdown 9539737
5 pparg 77.1 activates fas 10.3 others   00000001

Prediction Chart

Chart Legend

Prediction Table (39 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 atf2 9.1 fas 10.3 Human 100.00 19670268
2 egr1 21.1 fas 10.3 Human 100.00 9300687
3 fos 24.8 fas 10.3 Human 100.00 10903433
4 gli1 5 fas 10.3 Human 100.00 21135115
5 gli2 7 fas 10.3 Human 100.00 21135115
6 hdac1 11.3 fas 10.3 Human 100.00 22517765
7 jun 34.4 fas 10.3 Human 100.00 10903433
8 mirn146a 11.7 fas 10.3 Human 100.00 1
9 mirn20a 12.1 fas 10.3 Human 100.00 1
10 mirn98 20.1 fas 10.3 Human 100.00 1
11 mirn98 20.1 fas 10.3 Human 100.00 1
12 mirnlet7a 11.5 fas 10.3 Mouse 100.00 1
13 mirnlet7a 11.5 fas 10.3 Human 100.00 1
14 mirnlet7b 24 fas 10.3 Mouse 100.00 1
15 mirnlet7c 13.2 fas 10.3 Mouse 100.00 1
16 mirnlet7d 6.4 fas 10.3 Mouse 100.00 1
17 mirnlet7e 10.8 fas 10.3 Human 100.00 1
18 mirnlet7e 10.8 fas 10.3 Mouse 100.00 1
19 mirnlet7f 4.2 fas 10.3 Mouse 100.00 1
20 mirnlet7f 4.2 fas 10.3 Human 100.00 1
21 mirnlet7g 5.6 fas 10.3 Mouse 100.00 1
22 mirnlet7i 6.7 fas 10.3 Mouse 100.00 1
23 mirnlet7i 6.7 fas 10.3 Human 100.00 1
24 nfkb1 41.4 fas 10.3 Human 100.00 19628709
25 nfkbia 10.1 fas 10.3 Human 100.00 9733827
26 nfya 6.3 fas 10.3 Human 100.00 9261184
27 nfyc 2.7 fas 10.3 Human 100.00 9261184
28 rela 34.9 fas 10.3 Human 100.00 19628709
29 rela 34.9 fas 10.3 Human 100.00 16784892
30 sp1 40.7 fas 10.3 Human 100.00 22084312
31 srebf1 27.6 fas 10.3 Human 100.00 18420801
32 srebf2 5.2 fas 10.3 Human 100.00 9300785
33 stat1 16.4 fas 10.3 Human 100.00 16317104
34 stat3 34.7 fas 10.3 Human 100.00 16651438
35 sumo1 2.7 fas 10.3 Human 100.00 8906799
36 tfap2a 12.1 fas 10.3 Human 100.00 7528667
37 tp53 29.1 fas 10.3 Human 100.00 10101800
38 ybx1 4.4 fas 10.3 Human 100.00 10903433
39 yy1 12.3 fas 10.3 Human 100.00 16784892