Node

NCBI Gene

Symbol klf4 Gene ID 9314
IF 16.9% Link Number 12
Full Name Kruppel-like factor 4 (gut)
Aliases EZF,GKLF
Summary

This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Node Summary

PMID: 18396140

KLF4 also promotes adipogenesis by directly activating C/EBPβ transcription in early terminal differentiation.

PMID: 18396140

Promotes preadipocyte differentiation via activating C/EBPβ in cooperation with Egr2

PMID: 26241060

we have shown that the transcription factor Kruppel-like factor 4 (KLF4) governs mitochondrial biogenesis, metabolic function, dynamics, and autophagic clearance. Here, we determined that KLF4 binds to, cooperates with, and is requisite for optimal function of the estrogen-related receptor/PPARγ coactivator 1 (ERR/PGC-1) transcriptional regulatory module on metabolic and mitochondrial targets.

PMID: 27077806

In the heart, the transduction of cardiac mesenchymal progenitors (CMPs) with Klf4 and c-Myc (KM) was sufficient to drive the differentiation of these cells into adipocytes without the use of adipogenic stimulation cocktail, that is, insulin, 3-isobutyl-1-methylxanthine (IBMX) and dexamethasone.

PMID: 27077806

In the heart, the transduction of cardiac mesenchymal progenitors (CMPs) with Klf4 and c-Myc (KM) was sufficient to drive the differentiation of these cells into adipocytes without the use of adipogenic stimulation cocktail, that is, insulin, 3-isobutyl-1-methylxanthine (IBMX) and dexamethasone.

Node Expression

# PMID Condition Expression Material  
1 26111340 hMSC uncommitted High expression Up-Regulated MSC
2 26505482 low VS high IMF group (1 2) (1 2.914189527) IMF
3 18396140 0 0.5 1 2 4 8 12 24 4 5 6 22 6 5 4 3 3T3-L1
4 23967297 adi 6M std VS ob/ob (1 2) HFD-ob/obEadi(1 -10.7) mouse
5 23967297 HFD-adi(6 14) HFD-ageMadi(1 -9.5) mouse
6 23967297 HFD-adi(6 14) HFD-ageEadi(1 -5.3) mouse
7 23967297 6M HFD(1 2) HFD-Madi(1 4.2) mouse
8 15033539 dif(0 2 8 16 24 48 96)h dif(1 2 -10 -11 -11 -12 -13)fold 3T3-L1
9 12137940 0 2 8 16 24 1 6 3 2 2 3T3-L1
10 11445576   adipo-enriched 3T3-L1
11 11445576   adipo-enriched 3T3-L1
12 11445576 dif(-1 0 0.25 0.5 1 2 3 4 7 28) dif(10 9 8 8 7 6 5 3 2 1) 3T3-L1

Relation Chart

Chart Legend

Relation Table (12 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 ctnnb1 20.8 activates klf4 16.9 bind to DNA   22723415
2 gsk3b 8.1 activates klf4 16.9 signal transduction Overexpression and knockdown 26451280
3 klf 2.8 includes klf4 16.9 others Review 12620113
4 klf4 16.9 activates ppargc1b 5.1 bind to DNA ChIP,Co-IP,Histology,Microarray,RT-qPCR or RT-PCR,Western blot 26241060
5 klf4 16.9 activates crebbp 6.4 bind to protein Co-IP,Mutagenesis 10666450
6 klf4 16.9 activates cebpb 40.4 bind to DNA (IP)immunoprecipitation,Co-IP,Reporter,RT-qPCR or RT-PCR,Western blot 18396140
7 klf4 16.9 activates dlk2 2.1 bind to DNA   22306741
8 klf4 16.9 activates mirn206 9.6 bind to DNA   26053033
9 mirn10a 7.3 inhibits klf4 16.9 others cell assay,Cell culture and differentiation,Microarray,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 23696417
10 mirn10b 10.3 inhibits klf4 16.9 bind to RNA cell assay,Overexpression and knockdown,Reporter,RT-qPCR or RT-PCR,Western blot 24573354
11 mirn25 6 inhibits klf4 16.9 bind to RNA Overexpression and knockdown,Reporter,RT-qPCR or RT-PCR 25923408
12 timp3 14.9 inhibits klf4 16.9 others cell assay,Cell culture and differentiation,Reporter,RT-qPCR or RT-PCR 20056610

Prediction Chart

Chart Legend

Prediction Table (46 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 apc 4.4 klf4 16.9 Human 100.00 12387883
2 hdac1 11.3 klf4 16.9 Human 100.00 15051827
3 hdac2 3.5 klf4 16.9 Human 100.00 19486889
4 klf4 16.9 atf3 13 Human 100.00 21205742
5 klf4 16.9 birc5 9.5 Human 100.00 19361279
6 klf4 16.9 ccnb1 10.2 Human 100.00 14627709
7 klf4 16.9 ccnd1 26.2 Human 100.00 21224073
8 klf4 16.9 cdh1 8.4 Human 100.00 22407433
9 klf4 16.9 cdkn1a 16.2 Human 100.00 19737957
10 klf4 16.9 cdkn1a 16.2 Human 100.00 21224073
11 klf4 16.9 cdkn1b 7.6 Human 100.00 22170594
12 klf4 16.9 cdkn1c 2.9 Human 100.00 19544095
13 klf4 16.9 cyp1a1 3.1 Human 100.00 9651398
14 klf4 16.9 gdf15 7.3 Human 100.00 22750490
15 klf4 16.9 hspa8 3.7 Human 100.00 18379898
16 klf4 16.9 ifitm3 3.7 Human 100.00 21531817
17 klf4 16.9 il1b 10 Human 100.00 22449968
18 klf4 16.9 il6 26.3 Human 100.00 23846700
19 klf4 16.9 krt19 3.7 Human 100.00 10859317
20 klf4 16.9 lxn 5 Human 100.00 23364479
21 klf4 16.9 mmp2 15.9 Human 100.00 22407433
22 klf4 16.9 nanog 2.6 Human 100.00 19522013
23 klf4 16.9 odc1 5.4 Human 100.00 12297499
24 klf4 16.9 rara 11.3 Human 100.00 19531492
25 klf4 16.9 thbd 2.7 Human 100.00 19661484
26 klf4 16.9 vdr 19.5 Human 100.00 22677193
27 klf4 16.9 tp53 29.1 Human 100.00 21132436
28 klf4 16.9 rara 11.3 Human 100.00 19531492
29 klf4 16.9 atf3 13 Human 100.00 21205742
30 mirn128 6.9 klf4 16.9 Human 100.00 1
31 mirn128 6.9 klf4 16.9 Mouse 100.00 1
32 mirn135b 2.5 klf4 16.9 Human 100.00 1
33 mirn200b 5.6 klf4 16.9 Human 100.00 1
34 mirn200b 5.6 klf4 16.9 Mouse 100.00 1
35 mirn25 6 klf4 16.9 Human 100.00 1
36 mirn29a 11.7 klf4 16.9 Human 100.00 1
37 mirn29a 11.7 klf4 16.9 Mouse 100.00 1
38 mirn29b 16.3 klf4 16.9 Mouse 100.00 1
39 mirn29b 16.3 klf4 16.9 Human 100.00 1
40 mirn29c 9 klf4 16.9 Human 100.00 1
41 mirn29c 9 klf4 16.9 Mouse 100.00 1
42 pparg 77.1 klf4 16.9 Human 100.00 23275339
43 sox9 9.6 klf4 16.9 Human 100.00 18977346
44 tcf4 10.8 klf4 16.9 Human 100.00 18977346
45 tcf4 10.8 klf4 16.9 Human 100.00 18977346
46 tp63 3.9 klf4 16.9 Human 100.00 20972454