NCBI Gene
| Symbol | map3k12 | Gene ID | 7786 |
| IF | 0.3% | Link Number | 1 |
| Full Name | mitogen-activated protein kinase kinase kinase 12 | ||
| Aliases | DLK,MEKK12,MUK,ZPK,ZPKP1 | ||
| Summary | This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010] |
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Node Summary
PMID: 21585338
DLK (dual leucine zipper-bearing kinase) is a key regulator of development, cell differentiation and apoptosis. DLK is a novel transcriptional target of PPARγ with functional PPARγ-binding sites in its promoter.
PMID: 19270737
Immunoblot analyses and kinase assays performed on 3T3-L1 cells showed that the expression and activity of DLK substantially increase as differentiation occurs. Interestingly, DLK appears crucial for differentiation since its depletion by RNA interference impairs lipid accumulation as well as expression of the master regulators of adipogenesis C/EBPalpha and PPARgamma2 at both the mRNA and protein levels. In contrast, neither the expression nor the DNA binding activity of C/EBPbeta, an activator for C/EBPalpha and PPARgamma, is affected by DLK loss.
Relation Chart
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Relation Table (1 record)
| # | Source | IF(%) | Relation | Target | IF(%) | Type | Method | PMID |
|---|---|---|---|---|---|---|---|---|
| 1 | pparg | 77.1 | activates | map3k12 | 0.3 | bind to DNA | Bioinformatic,Cell culture and differentiation,ChIP,EMSA,Overexpression and knockdown,Western blot | 21585338 |
Prediction Chart
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Prediction Table (0 record)
| # | Source | IF(%) | Target | IF(%) | Species | Agreement | Computational Predictions / PMID |
|---|---|---|---|---|---|---|---|
Sorry, no matching records found. |
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