NCBI Gene
| Symbol | mirn130a | Gene ID | |
| IF | 8.4% | Link Number | 1 |
| Full Name | MI0000448 | ||
| Aliases | miR-130a,hsa-mir-130a,mmu-mir-130a | ||
| Summary | In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408), and in human (MI0000448, MI0000748). miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma. It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells. |
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Node Summary
PMID: 21135128
both miR-27a and miR-130a indeed suppress adipocyte differentiation through PPARγ downregulation. In 3T3-L1 cells, the levels of miR-27a and miR-130a are gradually decreased during adipogenesis, which is inversely correlated with expression levels of PPARγ.Furthermore, overexpression of miR-27a and miR-130a evidently suppresses adipocyte differentiation, concomitantly with PPARγ protein expression.
Node Expression
| # | PMID | Condition | Expression | Material | |
|---|---|---|---|---|---|
| 1 | 27562723 | C2C12 adipogenic VS med VS myogenic | (-1 2 1.5) | C2C12 | |
| 2 | 24307698 | spindle-shaped (SS) VS round-shaped (RS) hMSCs(1 2) | (-1.3 1.5) | MSC | |
| 3 | 26537990 | nonalcoholic fatty liver mice (1 2) | （0 -1.33) | Hepatic stellate cells (HSCs) | |
| 4 | 21731698 | wild-type VS leptin-deficient ob/ob mice (1 2) | (1 0.5) | MSC | |
| 5 | 25751060 | mice BMSCs 3mo VS 18 mo (3 18) | (3 -3) | MSC | |
| 6 | 21135128 | preadipocytes VS adipocytes (1 2) | (1 0.317) | preadipocyte | |
| 7 | 22496873 | group(1 2) | fold(1 -0.9) | mouse |
Relation Chart
Chart Legend
Relation Table (1 record)
| # | Source | IF(%) | Relation | Target | IF(%) | Type | Method | PMID |
|---|---|---|---|---|---|---|---|---|
| 1 | mirn130a | 8.4 | inhibits | pparg | 77.1 | bind to RNA | Cell culture and differentiation,Microarray,Overexpression and knockdown,Reporter,RT-qPCR or RT-PCR,Western blot | 21135128 |
Prediction Chart
Chart Legend
Prediction Table (27 records)
| # | Source | IF(%) | Target | IF(%) | Species | Agreement | Computational Predictions / PMID |
|---|---|---|---|---|---|---|---|
| 1 | mirn130a | 8.4 | tceal1 | 2.9 | Mouse | -0.01 | 3 |
| 2 | mirn130a | 8.4 | acvr2a | 4.8 | Mouse | 0.02 | 3 |
| 3 | mirn130a | 8.4 | mtf1 | 3.9 | Mouse | 0.62 | 3 |
| 4 | mirn130a | 8.4 | prkaa1 | 9.5 | Mouse | 0.05 | 3 |
| 5 | mirn130a | 8.4 | hla-b | 3.5 | Human | -0.01 | 3 |
| 6 | mirn130a | 8.4 | bmpr2 | 3.1 | Human | 100.00 | 1 |
| 7 | mirn130a | 8.4 | dnm2 | 3.4 | Human | 100.00 | 1 |
| 8 | mirn130a | 8.4 | ldlr | 12.1 | Human | 100.00 | 1 |
| 9 | mirn130a | 8.4 | pparg | 77.1 | Human | 100.00 | 1 |
| 10 | mirn130a | 8.4 | smad4 | 10.4 | Human | 100.00 | 2 |
| 11 | mirn130a | 8.4 | smad5 | 3.6 | Human | 100.00 | 1 |
| 12 | mirn130a | 8.4 | rab5a | 1.3 | Human | 100.00 | 1 |
| 13 | mirn130a | 8.4 | smad4 | 10.4 | Human | 100.00 | 2 |
| 14 | mirn130a | 8.4 | smad5 | 3.6 | Human | 100.00 | 1 |
| 15 | mirn130a | 8.4 | stk38l | 2.1 | Human | 100.00 | 1 |
| 16 | mirn130a | 8.4 | osmr | 6.5 | Mouse | -0.10 | 3 |
| 17 | mirn130a | 8.4 | p2ry10 | 2.5 | Mouse | -0.14 | 3 |
| 18 | mirn130a | 8.4 | slc25a27 | 4.2 | Mouse | -0.09 | 3 |
| 19 | mirn130a | 8.4 | zfp62 | 3.5 | Mouse | -0.09 | 3 |
| 20 | mirn130a | 8.4 | tceal1 | 2.9 | Mouse | -0.01 | 3 |
| 21 | mirn130a | 8.4 | acvr2a | 4.8 | Mouse | 0.02 | 3 |
| 22 | mirn130a | 8.4 | mtf1 | 3.9 | Mouse | 0.62 | 3 |
| 23 | mirn130a | 8.4 | prkaa1 | 9.5 | Mouse | 0.05 | 3 |
| 24 | mirn130a | 8.4 | mecom | 1.2 | Mouse | -0.76 | 3 |
| 25 | mirn130a | 8.4 | ptger3 | 4.6 | Mouse | 7 | |
| 26 | mirn130a | 8.4 | txnrd1 | 3.9 | Human | 4 | |
| 27 | mirn130a | 8.4 | hoxa5 | 2.2 | Human | 100.00 | 2 |
