Node

NCBI Gene

Symbol mirn145 Gene ID  
IF 7.8% Link Number 8
Full Name MI0000461
Aliases miR-145,hsa-mir-145,mmu-mir-145a,mmu-mir-145b,hsa-mir-145-5p
Summary  

Node Summary

PMID: 23886710

miR-143 and miR-145 directly target Osx and act as crucial regulators of osteogenic differentiation,consisting of another feedback loop with Klf4 and Osx in odontoblast differentiation.

Node Expression

# PMID Condition Expression Material  
1 23579070 T2D mice muscle (1 2) (0 -3.2) mouse
2 23827457 hMSC osteo-differentiation (1 4)day (0 0.92) MSC
3 26505482 low VS high IMF group (1 2) Up-Regulated IMF
4 24503542 Med-induced osteo-dif control vs exp (1 2) (0 1)  

Relation Chart

Chart Legend

Relation Table (8 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 dnmt3b 3.5 inhibits mirn145 7.8 epgenetic modification   25749421
2 mirn145 7.8 inhibits sp7 6 bind to RNA Reporter,RT-qPCR or RT-PCR,Western blot 23886710
3 mirn145 7.8 inhibits abhd5 7.3 bind to RNA   24732799
4 mirn145 7.8 inhibits dnmt3b 3.5 bind to RNA   25749421
5 mirn145 7.8 inhibits foxo1 17.2 bind to RNA   24732799
6 mirn145 7.8 inhibits irs1 11.6 bind to RNA Bioinformatic,Overexpression and knockdown,Reporter,RT-qPCR or RT-PCR,Triacylglycerol (TAG) Measurement,Western blot 23197937
7 mirn145 7.8 inhibits smad3 13.4 bind to RNA ChIP,ELISA,Overexpression and knockdown,Reporter,RT-qPCR or RT-PCR 25704091
8 pparg 77.1 activates mirn145 7.8 others ChIP,ELISA,Overexpression and knockdown,Reporter,RT-qPCR or RT-PCR 25704091

Prediction Chart

Chart Legend

Prediction Table (24 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 mirn145 7.8 adam17 3.1 Human 100.00 2
2 mirn145 7.8 bnip3 2.4 Human 100.00 2
3 mirn145 7.8 cbfb 5.6 Human 100.00 3
4 mirn145 7.8 cd44 14.8 Human 100.00 1
5 mirn145 7.8 cdh2 6.9 Human 100.00 2
6 mirn145 7.8 igf1r 12.1 Human 100.00 1
7 mirn145 7.8 irs2 14.9 Human 100.00 2
8 mirn145 7.8 klf5 6.7 Human 100.00 1
9 mirn145 7.8 ndufa4 2.2 Human 100.00 2
10 mirn145 7.8 nedd9 2.6 Human 100.00 2
11 mirn145 7.8 serpine1 15.7 Human 100.00 2
12 mirn145 7.8 sox2 7.5 Human 100.00 3
13 mirn145 7.8 vegfa 16.5 Human 100.00 2
14 mirn145 7.8 rps6kb1 5.9 Human 100.00 1
15 mirn145 7.8 rreb1 0.9 Human 100.00 1
16 mirn145 7.8 serpine1 15.7 Human 100.00 2
17 mirn145 7.8 sox2 7.5 Human 100.00 3
18 mirn145 7.8 vegfa 16.5 Human 100.00 2
19 mirn145 7.8 yes1 2.1 Human 100.00 3
20 mirn145 7.8 sox12 1.2 Mouse -0.14 3
21 mirn145 7.8 tgfb2 8 Mouse -0.06 3
22 mirn145 7.8 tnfaip2 6.1 Mouse -0.12 3
23 mirn145 7.8 fzd7 4.4 Human 100.00 1
24 mirn145 7.8 ppp3ca 2.2 Human 100.00 3