Node
NCBI Gene
| Symbol | mirn540 | Gene ID | |
| IF | 1.7% | Link Number | 1 |
| Full Name | MI0003518 | ||
| Aliases | miR-540,mmu-mir-540 | ||
| Summary | |||
Node Summary
PMID: 25560764
miR-540 was an essential negative regulator of adipogenic differentiation in adipose tissue-derived stromal cells (ADSCs). Lentivirus-mediated overexpression of miR-540 resulted in blockade of the expression of C/EBP-α and PPARγ, the two master transcription factors of adipogenesis, and deficient lipid accumulation, whereas inhibition of miR-540 promoted these processes. Target gene reporter assays showed that miR-540 directly targeted the 3'-untranslated region (3'UTR) of PPARγ, resulting in a decrease of PPARγ protein expression.
Node Expression
| # | PMID | Condition | Expression | Material | |
|---|---|---|---|---|---|
| 1 | 23579070 | T2D mice muscle (1 2) | (0 -3) | mouse |
Relation Chart
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Relation Table (1 record)
| # | Source | IF(%) | Relation | Target | IF(%) | Type | Method | PMID |
|---|---|---|---|---|---|---|---|---|
| 1 | mirn540 | 1.7 | inhibits | pparg | 77.1 | bind to RNA | Cell culture and differentiation,Overexpression and knockdown,Reporter,RT-qPCR or RT-PCR,Western blot | 25560764 |
Prediction Chart
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