Node

NCBI Gene

Symbol myc Gene ID 4609
IF 32.8% Link Number 1
Full Name v-myc avian myelocytomatosis viral oncogene homolog
Aliases MRTLC,bHLHe39,c-Myc,MYC
Summary

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

Node Summary

PMID: 25150255

Expression of MYC transcript and protein was found to accumulate during the initial course of differentiation. Loss-of-function analysis using siRNA mediated knockdown of MYC demonstrated inhibition of hormonally stimulated adipogenesis. MYC exhibited an early and sustained expression pattern that preceded down regulation of key suppressor genes, as well as induction of transcriptional and functional effectors. Glucocorticoid stimulation was identified as a necessary component for MYC induction and was found to impact adipogenesis in a concentration-dependent manner.

PMID: 27077806

In the heart, the transduction of cardiac mesenchymal progenitors (CMPs) with Klf4 and c-Myc (KM) was sufficient to drive the differentiation of these cells into adipocytes without the use of adipogenic stimulation cocktail, that is, insulin, 3-isobutyl-1-methylxanthine (IBMX) and dexamethasone.

Node Expression

# PMID Condition Expression Material  
1 27385551 human preadipocyte dif (0 96) hours (0 1.50939) preadipocyte
2 27385551 human preadipocyte dif (0 48) hours (0 1.44678) preadipocyte
3 27385551 human preadipocyte dif (6 48) hours (0 0.770477) preadipocyte
4 27385551 human preadipocyte dif (0 192) hours (0 -1.48229) preadipocyte
5 27385551 human preadipocyte dif (96 192) hours (0 -1.57252) preadipocyte
6 27108396 Control VS hADSC day 14 post-adipogenic induction (1 2.33) hADSC
7 27108396 Control VS hADSC day 7 post-adipogenic induction (1 2.21) hADSC
8 27108396 Control VS hADSC day 1 post-adipogenic induction (1 1.96) hADSC
9 26111340 hMSC DMI-Induced High expression Up-Regulated MSC
10 18060861 Bovine perimuscular fat preadipocytes dif (2 4 8)day (−7.74 −5.72 −4.87) preadipocyte
11 15556302 0 3 Up(1 5.2)fold MSC
12 15033539 dif(0 2 8 16 24 48 96)h dif(1 16 10 8 4 2 2)fold 3T3-L1
13 12646203 dif(0 1 3 5 7 9 14) fold(1 5 4 2 2 2 1) MSC
14 12631704 chondrogenic TF(0 1 2 7)d fold(1 -3 -3 -3) MSC
15 12631704 osteogenic TF(0 1 2 7)d fold(1 -3 -3 -3) MSC
16 12631704 osteogenic TF(1 2 7)d dif(2 -1 1) MSC
17 12138207 Wnt1-inhibit-dif(0 16 32 48)h,Day14 Down-regulated 3T3-L1
18 12137940 0 2 8 16 24 1 6 3 2 2 3T3-L1
19 11445576   preadipo-enriched 3T3-L1
20 11445576   adipo-enriched 3T3-L1

Node SNPs

# PMID SNPs Species Keyword
1 26580277 g.3350G>C Pig Meat Quality

Relation Chart

Chart Legend

Relation Table (1 record)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 myc 32.8 inhibits gadd45a 7 bind to DNA   10025511

Prediction Chart

Chart Legend

Prediction Table (149 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 ahr 6.7 myc 32.8 Human 100.00 16091746
2 apc 4.4 myc 32.8 Human 100.00 10229202
3 bcl6 12.9 myc 32.8 Human 100.00 21394099
4 bcl6 12.9 myc 32.8 Human 100.00 21394099
5 brca1 29.8 myc 32.8 Human 100.00 12032322
6 brca1 29.8 myc 32.8 Human 100.00 12032322
7 brca1 29.8 myc 32.8 Human 100.00 12032322
8 brca1 29.8 myc 32.8 Human 100.00 12032322
9 cebpa 40.7 myc 32.8 Human 100.00 12032779
10 cebpa 40.7 myc 32.8 Human 100.00 12032779
11 cnbp 0.8 myc 32.8 Human 100.00 23774591
12 ctcf 5.7 myc 32.8 Human 100.00 19568426
13 ctcf 5.7 myc 32.8 Human 100.00 12032779
14 ctcf 5.7 myc 32.8 Human 100.00 19568426
15 ctcf 5.7 myc 32.8 Human 100.00 12032779
16 ctnnb1 20.8 myc 32.8 Human 100.00 20300972
17 dlx5 6.2 myc 32.8 Human 100.00 19497851
18 dlx5 6.2 myc 32.8 Human 100.00 19497851
19 e2f1 22.1 myc 32.8 Human 100.00 11705881
20 e2f1 22.1 myc 32.8 Human 100.00 11705881
21 e2f4 6.7 myc 32.8 Human 100.00 17132729
22 e2f5 3.5 myc 32.8 Human 100.00 17132729
23 eno1 3.5 myc 32.8 Human 100.00 10681589
24 ep300 11.4 myc 32.8 Human 100.00 19279113
25 ep300 11.4 myc 32.8 Human 100.00 19279113
26 esr1 17.1 myc 32.8 Human 100.00 11517191
27 ets2 6 myc 32.8 Human 100.00 22108824
28 fos 24.8 myc 32.8 Human 100.00 2498162
29 fos 24.8 myc 32.8 Human 100.00 2498162
30 fubp1 3.4 myc 32.8 Human 100.00 11239393
31 hdac2 3.5 myc 32.8 Human 100.00 20493879
32 hdac3 4.1 myc 32.8 Human 100.00 19279113
33 hnf4a 8.6 myc 32.8 Human 100.00 23714368
34 jun 34.4 myc 32.8 Human 100.00 2498162
35 jun 34.4 myc 32.8 Human 100.00 2498162
36 lef1 5.2 myc 32.8 Human 100.00 19620402
37 lef1 5.2 myc 32.8 Human 100.00 19620402
38 mirn212 2.5 myc 32.8 Mouse 100.00 1
39 mirn98 20.1 myc 32.8 Human 100.00 1
40 mirnlet7a 11.5 myc 32.8 Mouse 100.00 1
41 mirnlet7b 24 myc 32.8 Mouse 100.00 1
42 mirnlet7c 13.2 myc 32.8 Mouse 100.00 3
43 mirnlet7d 6.4 myc 32.8 Mouse 100.00 1
44 mirnlet7f 4.2 myc 32.8 Mouse 100.00 1
45 mirnlet7g 5.6 myc 32.8 Mouse 100.00 1
46 mirnlet7i 6.7 myc 32.8 Mouse 100.00 1
47 mta1 4.1 myc 32.8 Human 100.00 12431981
48 mxi1 1.8 myc 32.8 Human 100.00 8838813
49 myb 11.6 myc 32.8 Human 100.00 1594249
50 mybl2 3.4 myc 32.8 Human 100.00 1594249
51 myc 32.8 ass1 6.5 Human 100.00 19934275
52 myc 32.8 atf3 13 Human 100.00 21384303
53 myc 32.8 bcat1 7.6 Human 100.00 1340466
54 myc 32.8 bcl2 14 Human 100.00 18809243
55 myc 32.8 cbfb 5.6 Human 100.00 9064279
56 myc 32.8 ccna2 5.6 Human 100.00 7608142
57 myc 32.8 ccnb1 10.2 Human 100.00 11522645
58 myc 32.8 ccnd1 26.2 Human 100.00 14757441
59 myc 32.8 ccnd2 13.3 Human 100.00 9339900
60 myc 32.8 ccne1 6 Human 100.00 20607601
61 myc 32.8 cdc25a 3 Human 100.00 8700224
62 myc 32.8 cdc25c 2.5 Human 100.00 22446629
63 myc 32.8 cdc34 2.5 Human 100.00 21252116
64 myc 32.8 cdk4 4.6 Human 100.00 22395148
65 myc 32.8 cdk6 12.9 Human 100.00 22395148
66 myc 32.8 cdkn1a 16.2 Human 100.00 16738884
67 myc 32.8 cdkn1a 16.2 Human 100.00 12553001
68 myc 32.8 cebpa 40.7 Human 100.00 19259613
69 myc 32.8 cflar 7.5 Human 100.00 20348907
70 myc 32.8 crebbp 6.4 Human 100.00 12776737
71 myc 32.8 cxcr4 5.4 Human 100.00 10229837
72 myc 32.8 dkk1 8.2 Human 100.00 20697356
73 myc 32.8 ep300 11.4 Human 100.00 12776737
74 myc 32.8 faslg 3 Human 100.00 12655294
75 myc 32.8 gata1 8.5 Human 100.00 18838534
76 myc 32.8 hdac2 3.5 Human 100.00 20697349
77 myc 32.8 hla-a 14.4 Human 100.00 8206526
78 myc 32.8 hla-b 3.5 Human 100.00 8206526
79 myc 32.8 hla-c 0.9 Human 100.00 8206526
80 myc 32.8 id2 7.4 Human 100.00 12545167
81 myc 32.8 ier3 7.1 Human 100.00 12360408
82 myc 32.8 ifna1 2.6 Human 100.00 16270532
83 myc 32.8 il6 26.3 Human 100.00 19259613
84 myc 32.8 junb 7.2 Human 100.00 18838534
85 myc 32.8 kras 5.5 Human 100.00 21252116
86 myc 32.8 ldha 8.9 Human 100.00 9723176
87 myc 32.8 mapk1 10.5 Human 100.00 21933022
88 myc 32.8 mme 5 Human 100.00 11519042
89 myc 32.8 mta1 4.1 Human 100.00 21813470
90 myc 32.8 mtdh 1.8 Human 100.00 17088530
91 myc 32.8 myb 11.6 Human 100.00 18408764
92 myc 32.8 ndrg1 3.4 Human 100.00 11936845
93 myc 32.8 nfe2 1 Human 100.00 18838534
94 myc 32.8 odc1 5.4 Human 100.00 21874531
95 myc 32.8 pcna 5.1 Human 100.00 18809243
96 myc 32.8 pgk1 3.1 Human 100.00 18809243
97 myc 32.8 pmaip1 4.2 Human 100.00 22216287
98 myc 32.8 prdx3 1.6 Human 100.00 12011429
99 myc 32.8 rb1 15.2 Human 100.00 11034201
100 myc 32.8 sfrp1 8.3 Human 100.00 20697356
101 myc 32.8 srsf1 2.2 Human 100.00 22545246
102 myc 32.8 st3gal1 2.4 Human 100.00 22547830
103 myc 32.8 tert 5.4 Human 100.00 10022128
104 myc 32.8 tfap4 4.8 Human 100.00 19270520
105 myc 32.8 tlx1 1.6 Human 100.00 20618946
106 myc 32.8 tp53 29.1 Human 100.00 8494784
107 myc 32.8 vegfa 16.5 Human 100.00 19398483
108 myc 32.8 zfp36 6 Human 100.00 22863009
109 myc 32.8 id2 7.4 Human 100.00 12545167
110 myc 32.8 ep300 11.4 Human 100.00 12776737
111 myc 32.8 atf3 13 Human 100.00 21384303
112 myc 32.8 bcl2 14 Human 100.00 18809243
113 myc 32.8 tp53 29.1 Human 100.00 8494784
114 myc 32.8 cbfb 5.6 Human 100.00 9064279
115 myc 32.8 gata1 8.5 Human 100.00 18838534
116 myc 32.8 tert 5.4 Human 100.00 10022128
117 myc 32.8 cd38 1.7 Human 100.00 11519042
118 myc 32.8 cdk2 6.7 Human 100.00 21384303
119 myc 32.8 hla-f 8.1 Human 100.00 8206526
120 nfkb1 41.4 myc 32.8 Human 100.00 18566231
121 pgr 4.6 myc 32.8 Human 100.00 22892083
122 pparg 77.1 myc 32.8 Human 100.00 11973610
123 prdm1 3.7 myc 32.8 Human 100.00 12032779
124 rb1 15.2 myc 32.8 Human 100.00 10200487
125 rbl1 1.7 myc 32.8 Human 100.00 17132729
126 rela 34.9 myc 32.8 Human 100.00 17018379
127 rela 34.9 myc 32.8 Human 100.00 18566231
128 rela 34.9 myc 32.8 Human 100.00 17018379
129 rela 34.9 myc 32.8 Human 100.00 18566231
130 runx3 7.9 myc 32.8 Human 100.00 20442291
131 runx3 7.9 myc 32.8 Human 100.00 20442291
132 sirt1 16.5 myc 32.8 Human 100.00 22245592
133 smad3 13.4 myc 32.8 Human 100.00 17132729
134 smad4 10.4 myc 32.8 Human 100.00 17132729
135 smad7 7.3 myc 32.8 Human 100.00 15555279
136 sp1 40.7 myc 32.8 Human 100.00 2057364
137 srsf1 2.2 myc 32.8 Human 100.00 22545246
138 stat3 34.7 myc 32.8 Human 100.00 20067773
139 stat4 7.2 myc 32.8 Human 100.00 10702306
140 tcf3 5.7 myc 32.8 Human 100.00 22384858
141 tcf3 5.7 myc 32.8 Human 100.00 21788410
142 tcf3 5.7 myc 32.8 Human 100.00 22384858
143 tcf3 5.7 myc 32.8 Human 100.00 21788410
144 tcf4 10.8 myc 32.8 Human 100.00 15928669
145 tcf4 10.8 myc 32.8 Human 100.00 15928669
146 tlx1 1.6 myc 32.8 Human 100.00 20618946
147 tp53 29.1 myc 32.8 Human 100.00 19411072
148 tp53 29.1 myc 32.8 Human 100.00 19411072
149 yy1 12.3 myc 32.8 Human 100.00 19279113