Node

NCBI Gene

Symbol neat1 Gene ID 283131
IF 1.6% Link Number 2
Full Name nuclear paraspeckle assembly transcript 1 (non-protein coding)
Aliases LINC00084,NCRNA00084,TncRNA,VINC
Summary

This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]

Node Summary

PMID: 23308182

Overexpressing NEAT1 transcripts potentiated the Clk1-mediated phosphorylation of SRp40, which facilitated the expression of PPARγ2 transcripts in preadipocytes.

PMID: 26459763

Using adipocyte-derived stem cells (ADSCs) isolated from wild-type and microRNA 140 (miR-140) knockout mice, we identify a novel miR-140/long noncoding RNA (lncRNA) NEAT1 signaling network necessary for adipogenesis. miR-140 knockout ADSCs have dramatically decreased adipogenic capabilities associated with downregulation of NEAT1 expression. We identified a miR-140 binding site in NEAT1 and found that mature miR-140 in the nucleus can physically interact with NEAT1, leading to increased NEAT1 expression.

Node Expression

# PMID Condition Expression Material  
1 27108396 Control VS hADSC day 1 post-adipogenic induction (1 2.29) hADSC
2 17697390 time(60 135 195 270) P/W ratio(1 0.91 1.97 6.75) IMF

Relation Chart

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Relation Table (2 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 mirn140 11.9 activates neat1 1.6 bind to RNA Overexpression and knockdown,Reporter 26459763
2 neat1 1.6 activates pparg 77.1 alternative splicing Cell culture and differentiation,Immunofluorescence,Mutagenesis,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 23308182

Prediction Chart

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Prediction Table (0 record)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
Sorry, no matching records found.