Node

NCBI Gene

Symbol nfat5 Gene ID 10725
IF 5.2% Link Number 1
Full Name nuclear factor of activated T-cells 5, tonicity-responsive
Aliases NF-AT5,NFATL1,NFATZ,OREBP,TONEBP
Summary

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Node Summary

PMID: 26042523

Here we report that TonEBP suppresses adipogenesis and insulin signaling by inhibiting expression of the key transcription factor PPARγ2. TonEBP binds to the PPARγ2 promoter and blocks the epigenetic transition of the locus which is required for the activation of the promoter.

Node Expression

# PMID Condition Expression Material  
1 27108396 Control VS hADSC day 14 post-adipogenic induction (1 -1.76) hADSC
2 27108396 Control VS hADSC day 7 post-adipogenic induction (1 -1.54) hADSC
3 27108396 Control VS hADSC day 1 post-adipogenic induction (1 -1.58) hADSC
4 27044590 group(MSC AD14day) (0 -1.01277418920791) hMSC

Relation Chart

Chart Legend

Relation Table (1 record)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 nfat5 5.2 inhibits pparg2 0.3 epgenetic modification Cell culture and differentiation,ChIP,Glucose Uptake,Methylation-specific PCR,Reporter,RT-qPCR or RT-PCR,Western blot 26042523

Prediction Chart

Chart Legend

Prediction Table (18 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 mirn149 32 nfat5 5.2 Mouse 0.87 4
2 mirn149 32 nfat5 5.2 Human 0.52 3
3 mirn17 20.6 nfat5 5.2 Human 100.00 1
4 mirn181a 21.9 nfat5 5.2 Mouse 100.00 2
5 mirn21 16.6 nfat5 5.2 Human 100.00 2
6 mirn211 9.1 nfat5 5.2 Mouse 100.00 1
7 mirn24 17.5 nfat5 5.2 Mouse 100.00 2
8 mirn30e 16.7 nfat5 5.2 Mouse 100.00 2
9 mirn31 11.8 nfat5 5.2 Human 100.00 1
10 mirn335 19 nfat5 5.2 Human 100.00 2
11 mirn335 19 nfat5 5.2 Human 100.00 2
12 mirn466a 11.6 nfat5 5.2 Mouse 1.65 3
13 mirn466b 4.7 nfat5 5.2 Mouse 1.58 3
14 mirn466c 5.5 nfat5 5.2 Mouse 1.58 3
15 mirn466d 10.1 nfat5 5.2 Mouse 1.58 3
16 mirn504 7.1 nfat5 5.2 Mouse 1.01 5
17 nfat5 5.2 ccl2 15.4 Human 100.00 22619484
18 nfat5 5.2 tnf 18.8 Human 100.00 11485737