Node

NCBI Gene

Symbol nr1h3 Gene ID 10062
IF 15.8% Link Number 12
Full Name nuclear receptor subfamily 1, group H, member 3
Aliases LXR-a,LXRA,RLD-1,LXR-alpha
Summary

The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Node Summary

PMID: 21030586

LXRs (liver X receptors): members of the nuclear receptor superfamily.These exist in two isoforms, LXRa and -b, that bind to DNA as heterodimers with RXR. Regulate lipid metabolism in mature adipocytes.

PMID: 15637161

Although activation of LXR leads to the induction of SREBP-1c gene expression and precursor protein, it has a very poor effect in inducing the mature nuclear form of the transcription factor.

Node Expression

# PMID Condition Expression Material  
1 27385551 human preadipocyte dif (0 192) hours (0 7.32134) preadipocyte
2 27385551 human preadipocyte dif (0 384) hours (0 6.54058) preadipocyte
3 27385551 human preadipocyte dif (0 96) hours (0 6.22335) preadipocyte
4 27385551 human preadipocyte dif (6 48) hours (0 3.9011) preadipocyte
5 27385551 human preadipocyte dif (48 96) hours (0 1.60817) preadipocyte
6 27385551 human preadipocyte dif (96 192) hours (0 1.09799) preadipocyte
7 27108396 Control VS hADSC day 21 post-adipogenic induction (1 1.71) hADSC
8 27108396 Control VS hADSC day 14 post-adipogenic induction (1 2.93) hADSC
9 27108396 Control VS hADSC day 7 post-adipogenic induction (1 1.6) hADSC
10 27044590 group(MSC AD14day) (0 1.23214891108823) hMSC
11 26205789 hADSC adipo-dif(7 21)day (1 0.23304591) ADSC
12 18637193 adipogenic TF   ADSC
13 15033539 dif(0 2 8 16 24 48 96)h dif(1 2 1 2 3 6 16)fold 3T3-L1
14 12646203 dif(0 1 3 5 7 9 14) fold(1 1 1.5 1 3 4 3) MSC
15 12138207 2 5 1 4 3T3-L1

Relation Chart

Chart Legend

Relation Table (12 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 GW3965 0.3 activates nr1h3 15.8 signal transduction Review 23765184
2 mirn613 0.4 inhibits nr1h3 15.8 bind to RNA Bioinformatic,ChIP,EMSA,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 21310851
3 nr1h3 15.8 activates srebf1 27.6 bind to DNA EMSA,RT-qPCR or RT-PCR,Western blot 15637161
4 nr1h3 15.8 inhibits ucp1 6.7 bind to DNA ChIP,EMSA,Histology,Overexpression and knockdown,Oxygen consumption,Phosphorylation 18195045
5 nr1h3 15.8 inhibits akt2 6.3 bind to DNA ELISA,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 23765184
6 nr1h3 15.8 inhibits plin1 16.2 bind to DNA ChIP,Immunofluorescence,Lipolysis assay,Microarray,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 21030586
7 nr1h3 15.8 inhibits sorbs1 9.3 bind to DNA ELISA,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 23765184
8 nr1h3 15.8 inhibits ppara-rxr 0.8 bind to protein EMSA,Reporter,Two-hybrid screening 8621574
9 nr1h3 15.8 inhibits pparg 77.1 bind to protein EMSA,Reporter,Two-hybrid screening 8621574
10 nr1h3 15.8 inhibits rxr 1.3 bind to protein EMSA,Reporter,Two-hybrid screening 8621574
11 nr1h3 15.8 inhibits slc2a4 13.6 others ELISA,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 23765184
12 pparg 77.1 activates nr1h3 15.8 bind to DNA cell assay,Cell culture and differentiation,ELISA,Overexpression and knockdown,Reporter,RT-qPCR or RT-PCR,Triacylglycerol (TAG) Measurement,Western blot 20693579

Prediction Chart

Chart Legend

Prediction Table (23 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 mirn613 0.4 nr1h3 15.8 Human 100.00 1
2 nr1h3 15.8 abca1 12.5 Human 100.00 11264984
3 nr1h3 15.8 abcg1 1.6 Human 100.00 16141411
4 nr1h3 15.8 abcg4 0.9 Human 100.00 16141411
5 nr1h3 15.8 apoe 10.5 Human 100.00 15171719
6 nr1h3 15.8 cetp 1 Human 100.00 18562803
7 nr1h3 15.8 pltp 4.8 Human 100.00 15171719
8 nr1h3 15.8 srebf1 27.6 Human 100.00 15171719
9 nr1h3 15.8 acot7 2.2 Human   1
10 nr1h3 15.8 agtrap 3.4 Human   1
11 nr1h3 15.8 c1qa 0.3 Human   1
12 nr1h3 15.8 capzb 3.1 Human   1
13 nr1h3 15.8 dhrs3 2.9 Human   1
14 nr1h3 15.8 eno1 3.5 Human   1
15 nr1h3 15.8 errfi1 3.8 Human   1
16 nr1h3 15.8 h6pd 5.4 Human   1
17 nr1h3 15.8 mtor 8.4 Human   1
18 nr1h3 15.8 prdm16 7.7 Human   1
19 nr1h3 15.8 runx3 7.9 Human   1
20 nr1h3 15.8 tnfrsf1b 2.5 Human   1
21 nr1h3 15.8 wdtc1 3.6 Human   1
22 nr1h3 15.8 wnt4 2.5 Human   1
23 pparg 77.1 nr1h3 15.8 Human 100.00 11604492