Node

NCBI Gene

Symbol per3 Gene ID 8863
IF 5% Link Number 2
Full Name period circadian clock 3
Aliases GIG13
Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]

Node Expression

# PMID Condition Expression Material  
1 27108396 Control VS hADSC day 21 post-adipogenic induction (1 -3.16) hADSC
2 27108396 Control VS hADSC day 14 post-adipogenic induction (1 -3.55) hADSC
3 27108396 Control VS hADSC day 7 post-adipogenic induction (1 -4.13) hADSC
4 27108396 Control VS hADSC day 1 post-adipogenic induction (1 -3.49) hADSC
5 27044590 group(MSC AD14day) (0 -2.1818903773378) hMSC
6 26111340 hMSC uncommitted High expression Up-Regulated MSC

Relation Chart

Chart Legend

Relation Table (2 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 glucocorticoic 0.8 inhibits per3 5 others Cell culture and differentiation,ChIP,Glucose Tolerance,Reporter,RT-qPCR or RT-PCR,Western blot 21228270
2 per3 5 inhibits pparg 77.1 others Cell culture and differentiation,ChIP,Glucose Tolerance,Reporter,RT-qPCR or RT-PCR,Western blot 21228270

Prediction Chart

Chart Legend

Prediction Table (6 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 arntl 4.6 per3 5 Human 100.00 22750052
2 clock 5.1 per3 5 Human 100.00 22750052
3 mirn21 16.6 per3 5 Human 100.00 2
4 mirn21 16.6 per3 5 Human 100.00 2
5 mirn26b 16 per3 5 Human 100.00 2
6 mirn26b 16 per3 5 Human 100.00 2