Node

NCBI Gene

Symbol pin1 Gene ID 5300
IF 3.1% Link Number 7
Full Name peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Aliases DOD,UBL5
Summary

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Node Summary

PMID: 24219242

PIN1, a peptidyl-prolyl cis/trans isomerase, has been reported in age-related bone homeostasis and adipogenesis. PIN1 mRNA and protein level were upregulated in a time-dependent manner during adipogenic differentiation, increasing until 1 day of odontogenic induction and then steadily declined during odontogenic differentiation. Treatment of a known PIN1 inhibitor, juglone, significantly increased odontogenic differentiation as confirmed by alkaline phosphatase (ALP) activity, calcium deposition, and mRNAs induction of odontogenic markers. On the contrary, adipogenic differentiation was dramatically reduced upon juglone treatment, with concomitant downregulation of lipid droplet accumulation and adipogenic marker genes

PMID: 25512367

Juglone and PIN1 siRNA inhibited LPS- and nicotine-induced osteoclastogenic cytokine expression in PDLCs.

PMID: 27475846

Pin1 enhances adipocyte differentiation by positively regulating the transcriptional activity of PPARγ. Pin1 is a peptidylprolyl cis/trans isomerase and it has a unique enzymatic activity of catalyzing isomerization of the peptide bond between phospho-serine/threonine and proline. In mouse embryonic fibroblasts and 3T3-L1 preadipocytes, overexpression of Pin1 enhances adipocyte differentiation whereas inhibition of Pin1 activity suppresses it. Pin1 interacts directly with and regulates the transcriptional activity of PPARγ, a key regulator of adipogenesis. In addition, ERK activity and Ser273 of PPARγ, a potential ERK phosphorylation target site, are important for the regulation of PPARγ function by Pin1 in 3T3-L1 cells.

Node Expression

# PMID Condition Expression Material  
1 27108396 Control VS hADSC day 14 post-adipogenic induction (1 -1.15) hADSC

Relation Chart

Chart Legend

Relation Table (7 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 juglone 0.3 inhibits pin1 3.1 bind to protein Review 24219242
2 pin1 3.1 activates pparg 77.1 bind to protein (IP)immunoprecipitation,Overexpression and knockdown,Phospholipase Activity Assay 27475846
3 pin1 3.1 activates irs1 11.6 phosphorylation (IP)immunoprecipitation,Glucose Tolerance,Glucose Uptake,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 21454638
4 pin1 3.1 activates akt2 6.3 bind to protein (IP)immunoprecipitation,Cell culture and differentiation,Histology,Overexpression and knockdown,Western blot 22412843
5 pin1 3.1 activates smad3 13.4 bind to protein (IP)immunoprecipitation,Cell culture and differentiation,Histology,Overexpression and knockdown,Western blot 22412843
6 pin1 3.1 inhibits crtc2 1 bind to protein (IP)immunoprecipitation,Cell culture and differentiation,Histology,Overexpression and knockdown,Western blot 22412843
7 pin1 3.1 inhibits pparg 77.1 bind to protein Cell culture and differentiation,Co-IP,Flow Cytometry,Overexpression and knockdown,Reporter,Western blot 19996102,22412843

Prediction Chart

Chart Legend

Prediction Table (5 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 e2f1 22.1 pin1 3.1 Human 100.00 20376080
2 mirn296 9.3 pin1 3.1 Mouse 0.57 3
3 mirn346 11.6 pin1 3.1 Mouse -0.08 3
4 mirn34c 9.8 pin1 3.1 Mouse 0.65 3
5 mirn449a 6.1 pin1 3.1 Mouse 0.58 3