NCBI Gene
| Symbol | prmt5 | Gene ID | 10419 |
| IF | 3.1% | Link Number | 3 |
| Full Name | protein arginine methyltransferase 5 | ||
| Aliases | HRMT1L5,IBP72,JBP1,SKB1,SKB1Hs | ||
| Summary | This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] |
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Node Summary
PMID: 26935580
The arginine methyltransferase Prmt5 was required for loop formation, and overexpression of Prmt5 resulted in premature loop formation and earlier onset of PPARγ2 expression. Prmt5 knockdown prevented binding of both MED1, a subunit of Mediator complex that facilitates enhancer-promoter interactions, and Brg1, the ATPase of the mammalian SWI/SNF chromatin remodeling enzyme required for PPARγ2 activation and adipogenic differentiation. The data indicate a dynamic association of Prmt5 with the regulatory sequences of the PPARγ2 gene that facilitates differentiation-dependent, three-dimensional organization of the locus.
Node Expression
Relation Chart
Chart Legend
Relation Table (3 records)
| # | Source | IF(%) | Relation | Target | IF(%) | Type | Method | PMID |
|---|---|---|---|---|---|---|---|---|
| 1 | coprs | 1.8 | activates | prmt5 | 3.1 | bind to protein | ChIP,Flow Cytometry,Microarray,RT-qPCR or RT-PCR,Western blot | 25681392 |
| 2 | prmt5 | 3.1 | activates | pparg | 77.1 | bind to DNA | Overexpression and knockdown | 26935580 |
| 3 | prmt5 | 3.1 | activates | dlk1 | 10.9 | bind to DNA | ChIP,Flow Cytometry,Microarray,RT-qPCR or RT-PCR,Western blot | 25681392 |
Prediction Chart
Chart Legend
Prediction Table (8 records)
| # | Source | IF(%) | Target | IF(%) | Species | Agreement | Computational Predictions / PMID |
|---|---|---|---|---|---|---|---|
| 1 | jak2 | 8.6 | prmt5 | 3.1 | Human | 100.00 | 10531356 |
| 2 | mirn149 | 32 | prmt5 | 3.1 | Mouse | -0.87 | 5 |
| 3 | mirn15a | 21.3 | prmt5 | 3.1 | Mouse | 100.00 | 2 |
| 4 | mirn211 | 9.1 | prmt5 | 3.1 | Mouse | -0.31 | 4 |
| 5 | mirn211 | 9.1 | prmt5 | 3.1 | Human | -0.31 | 4 |
| 6 | mirn760 | 4.6 | prmt5 | 3.1 | Mouse | -0.10 | 3 |
| 7 | mirn96 | 4 | prmt5 | 3.1 | Human | 100.00 | 1 |
| 8 | mirn96 | 4 | prmt5 | 3.1 | Human | 100.00 | 1 |
