NCBI Gene
| Symbol | rbm4 | Gene ID | 5936 |
| IF | 1.6% | Link Number | 6 |
| Full Name | RNA binding motif protein 4 | ||
| Aliases | LARKA,ZCCHC21,ZCRB3A,RBM4 | ||
| Summary | |||
Node Summary
PMID: 21518792
RBM4a functions as a multifunctional RNA-binding protein that is involved in splicing regulation and translation control.
PMID: 23129807
RBM4a reportedly reprograms the tissue-specific splicing network, which modulates development of muscles and pancreatic β-islets.
PMID: 25826570
RBM4a−/− mice exhibited metabolic phenotypes, including hyperglycemia, hypoinsulinemia, hyperlipidemia, and a reduced mass of interscapular (i) BATs. The regulatory activity of RBM4a on reprogramming the splicing profiles of FGFR2 and PKM gene, which contributed to the development and function of BAs.The direct binding of overexpressing RBM4a to MEF2C exon 10 was demonstrated to enhance the relative level of the MEF2Cγ-isoform which induced the expression of BA-specific factors, including RBM4a.
PMID: 24389249
A gradual increase in RBM4a protein was observed during the development of BATs and in differentiating primary adipocytes and C3H10T1/2 cells, which mediated the reprogramming of BA-associated splicing events. Elevated RBM4a reprogrammed the splicing profiles of IR, PPARγ, and Pref-1 genes, which participated in the different stages of adipogenesis.It is intriguing that RBM4a was observed to autoregulate its own splicing profile, subsequently enhancing transcription of full-length RBM4a mRNA .
PMID: 11988086
Upregulation of RBM4a relieved the repressive effect of Pref-1 on adipogenesis by enhancing the relative level of Pref-1C and Pref-1D transcripts, encoding the soluble membrane isoforms, whereas the large Pref-1A and Pref-1B transcripts functions as the adipogenic repressors.
PMID: 12807888
RBM4a enhanced the expression of insulin receptor B (IR-B) transcripts, which are dominantly expressed to mediate BA-associated signaling pathways in differentiating BAs.
PMID: 26857472
RNA-binding motif protein 4a (RBM4a) reportedly reprograms splicing profiles of the insulin receptor (IR) and myocyte enhancer factor 2C (MEF2C) genes, facilitating the differentiation of brown adipocytes.
PMID: 25826570
During the differentiation of brown adipocytes, upregulated RBM4 enhanced skipping of the MEF2Cγ region which functions as a transcriptional repressor. The presence of an overexpressed MEF2Cγ- isoform in turn induced transcriptional activity of the RBM4 promoter, constituting a positive feedback circuit in differentiating brown adipocytes. The RBM4-MEF2Cγ- network induced the expression of "myogenic" miR-1 to a greater extent than did PRDM17, BMP7 C/EBPβ, or UCP1 transcripts in C3H10T1/2 cells.
Relation Chart
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Relation Table (6 records)
| # | Source | IF(%) | Relation | Target | IF(%) | Type | Method | PMID |
|---|---|---|---|---|---|---|---|---|
| 1 | rbm4 | 1.6 | activates | mef2c | 6.2 | alternative splicing | 25826570 | |
| 2 | rbm4 | 1.6 | activates | pparg | 77.1 | alternative splicing | Cell culture and differentiation,Immunofluorescence,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot | 24389249 |
| 3 | rbm4 | 1.6 | activates | dlk1 | 10.9 | alternative splicing | Cell culture and differentiation,Immunofluorescence,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot | 24389249 |
| 4 | rbm4 | 1.6 | activates | insr | 3.7 | alternative splicing | 12807888 | |
| 5 | rbm4 | 1.6 | activates | fgfr2 | 2.7 | alternative splicing | 25826570 | |
| 6 | rbm4 | 1.6 | activates | pkm | 7.4 | alternative splicing | 25826570 |
Prediction Chart
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