NCBI Gene
| Symbol | setdb1 | Gene ID | 9869 |
| IF | 2.4% | Link Number | 5 |
| Full Name | SET domain, bifurcated 1 | ||
| Aliases | ESET,H3-K9-HMTase4,KG1T,KMT1E,TDRD21 | ||
| Summary | This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011] |
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Node Summary
PMID: 24188826
histone methyltransferase,specificity Catalytic H3K9me2/3 ,Promoting adipogenesis,Inhibiting osteogenesis
PMID: 17952062
The non-canonical WNT ligand WNT5A activates the histone methyltransferase SET domain bifurcated 1 (SETDB1).
PMID: 19414603
SETDB1 forms a complex with chromodomain helicase DNA-binding 7 (CHD7)and NEMO-like kinase (NLK) to inhibit the ability of PPARγ to transcriptionally activate its downstream metabolic target genes in the MSC cell line ST2 and in 3T3‑L1 cells.
Relation Chart
Chart Legend
Relation Table (5 records)
| # | Source | IF(%) | Relation | Target | IF(%) | Type | Method | PMID |
|---|---|---|---|---|---|---|---|---|
| 1 | ctnnb1 | 20.8 | activates | setdb1 | 2.4 | others | Review | 19581903 |
| 2 | gpi | 2.6 | activates | setdb1 | 2.4 | phosphorylation | 17952062 | |
| 3 | setdb1 | 2.4 | inhibits | runx2 | 28.4 | bind to DNA | (IHC) immunohistochemistry,Cell culture and differentiation,Gene knockout,Overexpression and knockdown,Reporter | 24188826 |
| 4 | setdb1 | 2.4 | inhibits | cebpa | 40.7 | epgenetic modification | Cell culture and differentiation,ChIP,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot | 20656681 |
| 5 | setdb1 | 2.4 | inhibits | pparg | 77.1 | epgenetic modification | Review | 19581903 |
Prediction Chart
Chart Legend
Prediction Table (9 records)
| # | Source | IF(%) | Target | IF(%) | Species | Agreement | Computational Predictions / PMID |
|---|---|---|---|---|---|---|---|
| 1 | mirn296 | 9.3 | setdb1 | 2.4 | Human | 100.00 | 1 |
| 2 | mirn296 | 9.3 | setdb1 | 2.4 | Human | 100.00 | 1 |
| 3 | mirn29a | 11.7 | setdb1 | 2.4 | Mouse | -0.18 | 3 |
| 4 | mirn29c | 9 | setdb1 | 2.4 | Mouse | -0.14 | 3 |
| 5 | mirn29c | 9 | setdb1 | 2.4 | Human | -0.14 | 3 |
| 6 | mirn346 | 11.6 | setdb1 | 2.4 | Mouse | -0.28 | 5 |
| 7 | mirn702 | 5.8 | setdb1 | 2.4 | Mouse | -0.04 | 3 |
| 8 | mirn7b | 6.8 | setdb1 | 2.4 | Mouse | 100.00 | 2 |
| 9 | mirn7b | 6.8 | setdb1 | 2.4 | Mouse | 100.00 | 2 |
