Node

NCBI Gene

Symbol spi1 Gene ID 6688
IF 7.4% Link Number 4
Full Name Spi-1 proto-oncogene
Aliases OF,PU.1,SFPI1,SPI-1,SPI-A
Summary

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Node Summary

PMID: 21903860

PU.1, which stimulates osteoclast-specific markers and RANK expression, can positively bind to the promoter of the M-CSFR gene for activation.

Node Expression

# PMID Condition Expression Material  
1 11445576   adipo-enriched 3T3-L1

Relation Chart

Chart Legend

Relation Table (4 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 csf1 9.1 activates spi1 7.4 bind to RNA Overexpression and knockdown 20039311
2 spi1 7.4 inhibits fasn 18.2 others Overexpression and knockdown,RT-qPCR or RT-PCR 25691151
3 spi1 7.4 inhibits pparg 77.1 others Overexpression and knockdown,RT-qPCR or RT-PCR 25691151
4 spi1 7.4 activates csf1r 3 bind to RNA Review 21903860

Prediction Chart

Chart Legend

Prediction Table (44 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 fos 24.8 spi1 7.4 Human 100.00 9988737
2 fos 24.8 spi1 7.4 Human 100.00 9988737
3 gata1 8.5 spi1 7.4 Human 100.00 10753833
4 gata1 8.5 spi1 7.4 Human 100.00 10753833
5 gata2 4.9 spi1 7.4 Human 100.00 19620289
6 gata2 4.9 spi1 7.4 Human 100.00 19620289
7 jun 34.4 spi1 7.4 Human 100.00 9988737
8 jun 34.4 spi1 7.4 Human 100.00 9988737
9 mirn155 20.6 spi1 7.4 Human 100.00 1
10 mirn155 20.6 spi1 7.4 Human 100.00 1
11 mirn34a 19.1 spi1 7.4 Human 100.00 1
12 mirn34a 19.1 spi1 7.4 Human 100.00 1
13 pou2f2 6.8 spi1 7.4 Human 100.00 12592383
14 satb1 3.3 spi1 7.4 Human 100.00 17694175
15 spi1 7.4 gata1 8.5 Human 100.00 20304827
16 spi1 7.4 bcl6 12.9 Human 100.00 19564417
17 spi1 7.4 bcl6 12.9 Human 100.00 19564417
18 spi1 7.4 ccl5 5.7 Human 100.00 10760799
19 spi1 7.4 cd163 4.4 Human 100.00 10725797
20 spi1 7.4 cd40 2.3 Human 100.00 10823830
21 spi1 7.4 csf1 9.1 Human 100.00 9632776
22 spi1 7.4 ctsg 2.4 Human 100.00 16019164
23 spi1 7.4 ctsk 4.6 Human 100.00 15304486
24 spi1 7.4 ctss 2.4 Human 100.00 16365419
25 spi1 7.4 cxcr1 1.4 Human 100.00 9867862
26 spi1 7.4 fes 2.9 Human 100.00 8657143
27 spi1 7.4 gata1 8.5 Human 100.00 20304827
28 spi1 7.4 il18 3.3 Human 100.00 14991611
29 spi1 7.4 il1b 10 Human 100.00 17386941
30 spi1 7.4 il5 2.9 Human 100.00 19487701
31 spi1 7.4 itga2b 0.9 Human 100.00 9305885
32 spi1 7.4 itgam 3.7 Human 100.00 15163413
33 spi1 7.4 itgax 2.9 Human 100.00 9295016
34 spi1 7.4 mapk1 10.5 Human 100.00 22075620
35 spi1 7.4 mme 5 Human 100.00 15892171
36 spi1 7.4 mnda 0.9 Human 100.00 8809111
37 spi1 7.4 ncf2 3.1 Human 100.00 10570299
38 spi1 7.4 nsfl1c 1.8 Human 100.00 10542290
39 spi1 7.4 p2ry10 2.5 Human 100.00 10567398
40 spi1 7.4 pebp1 2.6 Human 100.00 9334192
41 spi1 7.4 scarb1 4.4 Human 100.00 8007948
42 spi1 7.4 tlr4 2.5 Human 100.00 16785240
43 spi1 7.4 tnf 18.8 Human 100.00 10748079
44 spi1 7.4 tnfrsf11a 1 Human 100.00 16083856