NCBI Gene
| Symbol | rarres2 | Gene ID | 5919 |
| IF | 2.6% | Link Number | 0 |
| Full Name | retinoic acid receptor responder (tazarotene induced) 2 | ||
| Aliases | HP10433,TIG2,Chemerin | ||
| Summary | This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014] |
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Node Summary
PMID: 26164089
Chemerin inhibition of myogenesis and induction of adipogenesis in C2C12 myoblasts. Chemerin is an adipocyte-secreted adipokine that regulates the differentiation and metabolism of adipose through auto-/paracrine signaling. The adipokine Chemerin promoted the adipogenic differentiation potential and altered the fate of myoblast cells from myogenesis to adipogenesis, which contributed in part to the up-regulated adipocyte genes.
Node Expression
Node SNPs
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