Node

NCBI Gene

Symbol tp53 Gene ID 7157
IF 29.1% Link Number 7
Full Name tumor protein p53
Aliases BCC7,LFS1,P53,TRP53
Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]

Node Expression

# PMID Condition Expression Material  
1 27108396 Control VS hADSC day 7 post-adipogenic induction (1 -1.35) hADSC
2 27044590 group(MSC AD14day) (0 -1.07520232665353) hMSC
3 18060861 Bovine perimuscular fat preadipocytes dif (2 4 8)day (−7.45 −4.58 −4.45) preadipocyte
4 12631704 chondrogenic TF(0 1 2 7)d fold(1 3 3 3) MSC
5 12631704 osteogenic TF(0 1 2 7)d fold(1 3 3 3) MSC
6 12631704 osteogenic TF(1 2 7) 1 1 2 MSC
7 11445576 dif(-1 0 0.25 0.5 1 2 3 4 7 28) dif(10 9 8 8 7 6 5 3 2 1) 3T3-L1

Relation Chart

Chart Legend

Relation Table (7 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 age 5.1 activates tp53 29.1 others Cell culture and differentiation,ELISA,Histology,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 25855145
2 ager 1.8 activates tp53 29.1 bind to protein   23150674
3 ep300 11.4 activates tp53 29.1 bind to protein   17438265
4 kdm1a 1.3 inhibits tp53 29.1 others   22339659
5 stat3 34.7 activates tp53 29.1 bind to DNA cell assay,RT-qPCR or RT-PCR,Western blot 25462562
6 tp53 29.1 activates mirn34a 19.1 others Cell culture and differentiation 25524638
7 tp53 29.1 inhibits mirn17 20.6 others Cell culture and differentiation,ELISA,Histology,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 25855145

Prediction Chart

Chart Legend

Prediction Table (172 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 abl1 5.1 tp53 29.1 Human 100.00 11753601
2 crebbp 6.4 tp53 29.1 Human 100.00 15154850
3 e2f1 22.1 tp53 29.1 Human 100.00 15706352
4 e2f1 22.1 tp53 29.1 Human 100.00 8557038
5 e2f1 22.1 tp53 29.1 Human 100.00 15706352
6 e2f1 22.1 tp53 29.1 Human 100.00 8557038
7 egr1 21.1 tp53 29.1 Human 100.00 9242687
8 egr1 21.1 tp53 29.1 Human 100.00 9242687
9 ercc2 2.9 tp53 29.1 Human 100.00 22387547
10 esr1 17.1 tp53 29.1 Human 100.00 17681750
11 ets1 11.9 tp53 29.1 Human 100.00 10510472
12 ets1 11.9 tp53 29.1 Human 100.00 10510472
13 ets2 6 tp53 29.1 Human 100.00 10510472
14 ezh2 11.5 tp53 29.1 Human 100.00 20132185
15 fos 24.8 tp53 29.1 Human 100.00 10348347
16 fos 24.8 tp53 29.1 Human 100.00 10348347
17 hdac1 11.3 tp53 29.1 Human 100.00 15130752
18 hdac9 10.5 tp53 29.1 Human 100.00 15964798
19 hipk2 6.7 tp53 29.1 Human 100.00 12851404
20 hmga1 10.3 tp53 29.1 Human 100.00 20335021
21 hoxa10 2.9 tp53 29.1 Human 100.00 21993662
22 irf1 10.6 tp53 29.1 Human 100.00 19003964
23 jun 34.4 tp53 29.1 Human 100.00 22859294
24 jun 34.4 tp53 29.1 Human 100.00 22859294
25 klf4 16.9 tp53 29.1 Human 100.00 21132436
26 mcm2 5 tp53 29.1 Human 100.00 17957142
27 mcm4 4.8 tp53 29.1 Human 100.00 17957142
28 mirn125a 12 tp53 29.1 Human 100.00 1
29 mirn125a 12 tp53 29.1 Human 100.00 1
30 mirn125b 15.7 tp53 29.1 Human 100.00 2
31 mirn125b 15.7 tp53 29.1 Human 100.00 2
32 mirn1285 1.6 tp53 29.1 Human 100.00 1
33 mirn1285 1.6 tp53 29.1 Human 100.00 1
34 mirn150 8.5 tp53 29.1 Human 100.00 1
35 mirn150 8.5 tp53 29.1 Human 100.00 1
36 mirn214 10.2 tp53 29.1 Human 100.00 3
37 mirn214 10.2 tp53 29.1 Human 100.00 3
38 mirn27a 16.9 tp53 29.1 Human 100.00 1
39 mirn504 7.1 tp53 29.1 Human 100.00 2
40 mirn504 7.1 tp53 29.1 Human 100.00 2
41 mirn98 20.1 tp53 29.1 Human 100.00 1
42 mirn98 20.1 tp53 29.1 Human 100.00 1
43 mirn98 20.1 tp53 29.1 Human 100.00 1
44 myc 32.8 tp53 29.1 Human 100.00 8494784
45 myc 32.8 tp53 29.1 Human 100.00 8494784
46 nfkb1 41.4 tp53 29.1 Human 100.00 10348347
47 nfya 6.3 tp53 29.1 Human   1
48 nr3c1 15.3 tp53 29.1 Human 100.00 17016446
49 nupr1 4.4 tp53 29.1 Human 100.00 22858377
50 pax2 2.6 tp53 29.1 Human 100.00 8521821
51 pparg 77.1 tp53 29.1 Human 100.00 14960510
52 rela 34.9 tp53 29.1 Human 100.00 10348347
53 rela 34.9 tp53 29.1 Human 100.00 10348347
54 sirt1 16.5 tp53 29.1 Human 100.00 15632193
55 sox6 4.3 tp53 29.1 Human 100.00 21084391
56 stat1 16.4 tp53 29.1 Human 100.00 14602726
57 stat1 16.4 tp53 29.1 Human 100.00 14602726
58 stat3 34.7 tp53 29.1 Human 100.00 20043094
59 stat3 34.7 tp53 29.1 Human 100.00 20043094
60 tfdp1 5.5 tp53 29.1 Human 100.00 8557038
61 tp53 29.1 tp53 29.1 Human 100.00 22532570
62 tp53 29.1 brca1 29.8 Human 100.00 11306454
63 tp53 29.1 brca1 29.8 Human 100.00 11306454
64 tp53 29.1 myc 32.8 Human 100.00 19411072
65 tp53 29.1 id2 7.4 Human 100.00 16557594
66 tp53 29.1 gli2 7 Human 100.00 18813803
67 tp53 29.1 klf2 11.7 Human 100.00 23202365
68 tp53 29.1 e2f1 22.1 Human 100.00 8557038
69 tp53 29.1 foxo3 10.7 Human 100.00 19299143
70 tp53 29.1 atf3 13 Human 100.00 12372430
71 tp53 29.1 bcl2 14 Human 100.00 19411072
72 tp53 29.1 id1 8.9 Human 100.00 16557594
73 tp53 29.1 brca1 29.8 Human 100.00 11306454
74 tp53 29.1 tert 5.4 Human 100.00 17656250
75 tp53 29.1 egr1 21.1 Human 100.00 16990849
76 tp53 29.1 abcb1 4 Human 100.00 10029407
77 tp53 29.1 akt1 4.3 Human 100.00 12485897
78 tp53 29.1 ankrd1 3.5 Human 100.00 20599664
79 tp53 29.1 atf3 13 Human 100.00 12372430
80 tp53 29.1 bax 6.4 Human 100.00 10566557
81 tp53 29.1 bcl2 14 Human 100.00 19411072
82 tp53 29.1 bcl3 4.3 Human 100.00 12808109
83 tp53 29.1 bglap 4.6 Human 100.00 21964930
84 tp53 29.1 birc5 9.5 Human 100.00 17124180
85 tp53 29.1 brca1 29.8 Human 100.00 11306454
86 tp53 29.1 btg2 6.4 Human 100.00 16581545
87 tp53 29.1 cav1 6.3 Human 100.00 10684646
88 tp53 29.1 ccna2 5.6 Human 100.00 8270002
89 tp53 29.1 ccnb1 10.2 Human 100.00 11892838
90 tp53 29.1 ccnb2 4.8 Human 100.00 12889596
91 tp53 29.1 ccnd1 26.2 Human 100.00 12808109
92 tp53 29.1 cdk1 5.2 Human 100.00 12889596
93 tp53 29.1 cdk4 4.6 Human 100.00 17530187
94 tp53 29.1 cdkn1a 16.2 Human 100.00 10327058
95 tp53 29.1 cdkn1a 16.2 Human 100.00 17344317
96 tp53 29.1 cdkn1b 7.6 Human 100.00 15988033
97 tp53 29.1 ckm 2 Human 100.00 8389468
98 tp53 29.1 cryab 7.5 Human 100.00 21556774
99 tp53 29.1 ctnnb1 20.8 Human 100.00 19411072
100 tp53 29.1 ddb1 2.1 Human 100.00 16357511
101 tp53 29.1 ddb1 2.1 Human 100.00 19382146
102 tp53 29.1 dkk1 8.2 Human 100.00 15229249
103 tp53 29.1 dnmt1 8.5 Human 100.00 20570896
104 tp53 29.1 dnmt1 8.5 Human 100.00 20570896
105 tp53 29.1 dusp1 10.7 Human 100.00 12890671
106 tp53 29.1 e2f1 22.1 Human 100.00 8557038
107 tp53 29.1 e2f3 5.4 Human 100.00 20428827
108 tp53 29.1 egfr 12.4 Human 100.00 10029407
109 tp53 29.1 egr1 21.1 Human 100.00 16990849
110 tp53 29.1 esr1 17.1 Human 100.00 21655924
111 tp53 29.1 ezh2 11.5 Human 100.00 15208672
112 tp53 29.1 ezh2 11.5 Human 100.00 21165554
113 tp53 29.1 fas 10.3 Human 100.00 10101800
114 tp53 29.1 fdxr 0.9 Human 100.00 12370809
115 tp53 29.1 fgf2 9.4 Human 100.00 10029407
116 tp53 29.1 foxo3 10.7 Human 100.00 19299143
117 tp53 29.1 gadd45a 7 Human 100.00 10566557
118 tp53 29.1 gadd45a 7 Human 100.00 17344317
119 tp53 29.1 gdf15 7.3 Human 100.00 10618379
120 tp53 29.1 gli2 7 Human 100.00 18813803
121 tp53 29.1 hipk2 6.7 Human 100.00 11740489
122 tp53 29.1 hnf4a 8.6 Human 100.00 16895524
123 tp53 29.1 hr 1.3 Human 100.00 15489903
124 tp53 29.1 id1 8.9 Human 100.00 16557594
125 tp53 29.1 id2 7.4 Human 100.00 16557594
126 tp53 29.1 ier3 7.1 Human 100.00 12360408
127 tp53 29.1 igf1r 12.1 Human 100.00 17097318
128 tp53 29.1 igfbp3 10.7 Human 100.00 10101800
129 tp53 29.1 klf2 11.7 Human 100.00 23202365
130 tp53 29.1 map4 2.1 Human 100.00 19411072
131 tp53 29.1 mcl1 2.9 Human 100.00 19411072
132 tp53 29.1 mcm7 3.8 Human 100.00 15899946
133 tp53 29.1 mdm2 4.2 Human 100.00 10566557
134 tp53 29.1 met 8 Human 100.00 21831840
135 tp53 29.1 mgmt 1.2 Human 100.00 19846904
136 tp53 29.1 mki67 5.1 Human 100.00 14675138
137 tp53 29.1 mmp1 9 Human 100.00 15108353
138 tp53 29.1 mmp2 15.9 Human 100.00 11792711
139 tp53 29.1 myc 32.8 Human 100.00 19411072
140 tp53 29.1 nfkb1 41.4 Human 100.00 15988033
141 tp53 29.1 pdgfrb 8.6 Human 100.00 18697203
142 tp53 29.1 pias3 1.7 Human 100.00 11877452
143 tp53 29.1 plk3 5.9 Human 100.00 16581545
144 tp53 29.1 pmaip1 4.2 Human 100.00 14695212
145 tp53 29.1 pold1 5 Human 100.00 11375983
146 tp53 29.1 ppp2r4 5 Human 100.00 10787423
147 tp53 29.1 prc1 5.5 Human 100.00 12889596
148 tp53 29.1 pten 14.7 Human 100.00 17344317
149 tp53 29.1 ptpn13 4.3 Human 100.00 11696979
150 tp53 29.1 rb1 15.2 Human 100.00 8119988
151 tp53 29.1 rela 34.9 Human 100.00 15988033
152 tp53 29.1 slc2a1 5.2 Human 100.00 22483234
153 tp53 29.1 smad3 13.4 Human 100.00 21900401
154 tp53 29.1 stat3 34.7 Human 100.00 11809683
155 tp53 29.1 tceal1 2.9 Human 100.00 20421190
156 tp53 29.1 tcf7l2 5.5 Human 100.00 14990988
157 tp53 29.1 tert 5.4 Human 100.00 17656250
158 tp53 29.1 thbs1 11.5 Human 100.00 10029407
159 tp53 29.1 tp53 29.1 Human 100.00 22532570
160 tp53 29.1 tyms 5.5 Human 100.00 21351099
161 tp53 29.1 vcan 7.5 Human 100.00 12438652
162 tp53 29.1 vegfa 16.5 Human 100.00 16684540
163 tp53 29.1 vegfa 16.5 Human 100.00 11559575
164 tp53 29.1 rela 34.9 Human 100.00 15988033
165 tp53 29.1 tcf7l2 5.5 Human 100.00 14990988
166 tp53 29.1 e2f3 5.4 Human 100.00 20428827
167 tp53 29.1 aqp3 1.7 Human 100.00 11231003
168 tp53 29.1 cdk2 6.7 Human 100.00 12732645
169 tp53 29.1 gstp1 1.6 Human 100.00 18505928
170 tp53 29.1 mad1l1 2.5 Human 100.00 12876282
171 tp53 29.1 uhrf1 2.2 Human 100.00 18220474
172 yy1 12.3 tp53 29.1 Human 100.00 10787423