Node

NCBI Gene

Symbol tsc22d3 Gene ID 1831
IF 13.6% Link Number 1
Full Name TSC22 domain family, member 3
Aliases DIP,DSIPI,GILZ,TSC-22R,hDIP
Summary

The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Node Summary

PMID: 12671681

We have shown that a GC-induced leucine-zipper protein (GILZ) antagonizes adipocyte differentiation. GILZ binds to a tandem repeat of CCAAT/enhancer-binding protein (C/EBP) binding sites in the promoter of the gene encoding peroxisome-proliferator-activated receptor-gamma2 (PPAR-gamma2), and inhibits its transcription as a sequence-specific transcriptional repressor.

Node Expression

# PMID Condition Expression Material  
1 27108396 Control VS hADSC day 21 post-adipogenic induction (1 4.49) hADSC
2 27108396 Control VS hADSC day 14 post-adipogenic induction (1 4) hADSC
3 27108396 Control VS hADSC day 7 post-adipogenic induction (1 4.38) hADSC
4 27108396 Control VS hADSC day 1 post-adipogenic induction (1 4.32) hADSC
5 26111340 hMSC High Density & DMI-Induced High expression Up-Regulated MSC
6 26111340 hMSC DMI-Induced High expression Up-Regulated MSC
7 24130839 porcine intramuscular/subcutaneous adipocyte-dif(0 2 4)day (1.3 1.7 2) IMF
8 15556302 0 3 Up(1 7.5)fold MSC
9 12631704 chondrogenic TF(0 1 2 7)d fold(1 3 3 3) MSC
10 12631704 osteogenic TF(0 1 2 7)d fold(1 3 3 3) MSC
11 12631704 osteogenic TF(1 2 7) 1 1 2 MSC

Relation Chart

Chart Legend

Relation Table (1 record)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 tsc22d3 13.6 inhibits pparg 77.1 bind to DNA Cell culture and differentiation,ChIP,EMSA,Northern blot,Overexpression and knockdown,RT-qPCR or RT-PCR,Western blot 12671681

Prediction Chart

Chart Legend

Prediction Table (47 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 mirn10a 7.3 tsc22d3 13.6 Mouse -0.76 4
2 mirn10b 10.3 tsc22d3 13.6 Mouse -0.76 4
3 mirn10b 10.3 tsc22d3 13.6 Mouse -0.76 4
4 mirn1192 4.6 tsc22d3 13.6 Mouse -0.40 15
5 mirn125a 12 tsc22d3 13.6 Mouse -0.76 10
6 mirn140 11.9 tsc22d3 13.6 Mouse 0.06 3
7 mirn140 11.9 tsc22d3 13.6 Mouse 0.06 3
8 mirn140 11.9 tsc22d3 13.6 Mouse 0.06 3
9 mirn185 22.6 tsc22d3 13.6 Mouse -0.31 4
10 mirn185 22.6 tsc22d3 13.6 Mouse -0.76 7
11 mirn185 22.6 tsc22d3 13.6 Mouse -0.76 4
12 mirn18a 10.6 tsc22d3 13.6 Human 305.00 1
13 mirn1941 5 tsc22d3 13.6 Mouse -0.76 7
14 mirn1941 5 tsc22d3 13.6 Mouse -0.76 4
15 mirn19b 13.1 tsc22d3 13.6 Human 308.00 1
16 mirn214 10.2 tsc22d3 13.6 Mouse -0.02 3
17 mirn222 12.6 tsc22d3 13.6 Mouse 0.02 3
18 mirn222 12.6 tsc22d3 13.6 Mouse 0.02 3
19 mirn30a 17.6 tsc22d3 13.6 Mouse -0.76 5
20 mirn30b 13.9 tsc22d3 13.6 Mouse -0.76 5
21 mirn30b 13.9 tsc22d3 13.6 Mouse -0.76 5
22 mirn30c 14.4 tsc22d3 13.6 Mouse -0.76 5
23 mirn30c 14.4 tsc22d3 13.6 Mouse -0.76 5
24 mirn30d 8.8 tsc22d3 13.6 Mouse -0.76 5
25 mirn30d 8.8 tsc22d3 13.6 Mouse -0.76 5
26 mirn30e 16.7 tsc22d3 13.6 Mouse -0.76 5
27 mirn30e 16.7 tsc22d3 13.6 Mouse -0.76 5
28 mirn31 11.8 tsc22d3 13.6 Mouse -0.76 10
29 mirn379 4 tsc22d3 13.6 Mouse -0.76 5
30 mirn379 4 tsc22d3 13.6 Mouse -0.76 5
31 mirn384 1.6 tsc22d3 13.6 Mouse -0.76 5
32 mirn411 3.4 tsc22d3 13.6 Mouse -0.76 4
33 mirn423 10.6 tsc22d3 13.6 Mouse -0.76 3
34 mirn423 10.6 tsc22d3 13.6 Mouse -0.76 3
35 mirn466a 11.6 tsc22d3 13.6 Mouse -0.76 3
36 mirn466d 10.1 tsc22d3 13.6 Mouse -0.39 7
37 mirn466d 10.1 tsc22d3 13.6 Mouse -0.76 4
38 mirn467e 3.1 tsc22d3 13.6 Mouse -0.76 5
39 mirn483 3.7 tsc22d3 13.6 Mouse -0.76 10
40 mirn483 3.7 tsc22d3 13.6 Mouse -0.01 3
41 mirn484 13.5 tsc22d3 13.6 Human 332.00 1
42 mirn499 1.2 tsc22d3 13.6 Mouse -0.02 3
43 mirn702 5.8 tsc22d3 13.6 Mouse -0.01 3
44 mirn877 6.8 tsc22d3 13.6 Human 342.00 1
45 mirn92a 30.6 tsc22d3 13.6 Mouse -0.76 3
46 tsc22d3 13.6 ccnd1 26.2 Human 100.00 19814803
47 tsc22d3 13.6 cdkn1a 16.2 Human 100.00 19814803