Node

NCBI Gene

Symbol twist1 Gene ID 7291
IF 13.6% Link Number 5
Full Name twist family bHLH transcription factor 1
Aliases ACS3,BPES2,BPES3,CRS,CRS1,CSO,SCS,TWIST,bHLHa38
Summary

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. [provided by RefSeq, Jul 2008]

Node Summary

PMID: 25128964

Twist 1gene transcription was significantly downregulated in obese subjects. Twist 1 was upregulated during 3T3-L1 adipocyte differentiation. Retroviral interference of Twist 1 expression enhanced the expression of PPARγ on day 4 of hormone-induced differentiation.

PMID: 27825360

The expression levels of Twist 1 and PPARγ were induced during differentiation in 3T3-L1 adipocytes. Application of either a PPARγ agonist (pioglitazone) or antagonist (T0070907) influenced Twist 1 expression, with up-regulation of Twist 1 under pioglitazone (1 μM, 24 h) and down-regulation of Twist 1 under T0070907 (100 μM, 24 h) exposure. Furthermore, the retroviral interference of Twist 1 decreased the protein and mRNA expression of PPARγ, while Twist 1 overexpression had the opposite effect.

Node Expression

# PMID Condition Expression Material  
1 27385551 human preadipocyte dif (0 48) hours (0 1.18007) preadipocyte
2 27108396 Control VS hADSC day 21 post-adipogenic induction (1 2.02) hADSC
3 27108396 Control VS hADSC day 14 post-adipogenic induction (1 1.94) hADSC
4 27108396 Control VS hADSC day 7 post-adipogenic induction (1 2.13) hADSC
5 27108396 Control VS hADSC day 1 post-adipogenic induction (1 1.38) hADSC
6 25982065 hMSC LMNA 465 mutation Adipo dif (1 2) (0 1.86) MSC
7 23894377 control VS cold-induced Liver (1 2) (1 2.2939558) mouse
8 16420668 dif(0 0.25 0.5 1 2 3 7 14) log2(0.6 0.8 1 0.7 1.1 1.2 1.1 1) 3T3-L1

Relation Chart

Chart Legend

Relation Table (5 records)

 
# Source IF(%) Relation Target IF(%) Type Method PMID
1 hes4 1 inhibits twist1 13.6 bind to protein   25579220
2 mirn1 14.7 inhibits twist1 13.6 bind to RNA RT-qPCR or RT-PCR 26071255
3 mirn33b 2.6 inhibits twist1 13.6 bind to RNA   25868853
4 twist1 13.6 inhibits pparg 77.1 others Overexpression and knockdown,RT-qPCR or RT-PCR 25128964
5 twist1 13.6 inhibits runx2 28.4 bind to DNA ChIP,Overexpression and knockdown,Reporter 24703637

Prediction Chart

Chart Legend

Prediction Table (54 records)

 
# Source IF(%) Target IF(%) Species Agreement Computational Predictions / PMID
1 ezh2 11.5 twist1 13.6 Human 100.00 23836662
2 hdac2 3.5 twist1 13.6 Human 100.00 23836662
3 hif1a 21.7 twist1 13.6 Human 100.00 23623921
4 hif1a 21.7 twist1 13.6 Human 100.00 23623921
5 hmga1 10.3 twist1 13.6 Human 100.00 22276142
6 mirn151 2.6 twist1 13.6 Mouse -0.07 3
7 mirn151 2.6 twist1 13.6 Mouse -0.07 3
8 mirn212 2.5 twist1 13.6 Mouse -0.07 3
9 mirn214 10.2 twist1 13.6 Mouse -0.16 4
10 mirn2861 12.3 twist1 13.6 Mouse -0.05 3
11 mirn31 11.8 twist1 13.6 Mouse -0.06 3
12 mirn409 1.4 twist1 13.6 Mouse -0.01 3
13 mirn92a 30.6 twist1 13.6 Mouse -0.03 3
14 mirnlet7c 13.2 twist1 13.6 Mouse -0.07 3
15 per2 5.2 twist1 13.6 Human 100.00 23836662
16 pou2f1 4.8 twist1 13.6 Human 100.00 23836662
17 rela 34.9 twist1 13.6 Human 100.00 22253230
18 rela 34.9 twist1 13.6 Human 100.00 22253230
19 runx2 28.4 twist1 13.6 Human 100.00 22641097
20 runx2 28.4 twist1 13.6 Human 100.00 22641097
21 stat3 34.7 twist1 13.6 Human 100.00 23623921
22 stat3 34.7 twist1 13.6 Human 100.00 23623921
23 twist1 13.6 cdh1 8.4 Human   1
24 twist1 13.6 ybx1 4.4 Human   1
25 twist1 13.6 bcl2 14 Human 100.00 23095743
26 twist1 13.6 akr1c2 5.1 Human 100.00 19051271
27 twist1 13.6 akt2 6.3 Human 100.00 21876555
28 twist1 13.6 bcl2 14 Human 100.00 23095743
29 twist1 13.6 cd44 14.8 Human 100.00 17487558
30 twist1 13.6 cdh1 8.4 Human 100.00 15311212
31 twist1 13.6 cdh2 6.9 Human 100.00 21796367
32 twist1 13.6 dkk1 8.2 Human 100.00 18453541
33 twist1 13.6 dnm3 3.5 Human 100.00 18033314
34 twist1 13.6 esr1 17.1 Human 100.00 22056872
35 twist1 13.6 fgf2 9.4 Human 100.00 11169739
36 twist1 13.6 fn1 18 Human 100.00 20646316
37 twist1 13.6 fos 24.8 Human 100.00 19051271
38 twist1 13.6 gdf15 7.3 Human 100.00 19051271
39 twist1 13.6 icam1 9.8 Human 100.00 17487558
40 twist1 13.6 itgb1 6.7 Human 100.00 17487558
41 twist1 13.6 mapk1 10.5 Human 100.00 23222305
42 twist1 13.6 mapk3 8 Human 100.00 23222305
43 twist1 13.6 mmp1 9 Human 100.00 23222305
44 twist1 13.6 mmp2 15.9 Human 100.00 20646316
45 twist1 13.6 myb 11.6 Human 100.00 19051271
46 twist1 13.6 nr2f1 3.9 Human 100.00 19051271
47 twist1 13.6 rap1a 1.4 Human 100.00 19051271
48 twist1 13.6 rbl2 4.3 Human 100.00 19051271
49 twist1 13.6 srpx 4.2 Human 100.00 19051271
50 twist1 13.6 ybx1 4.4 Human 100.00 21876555
51 twist1 13.6 fos 24.8 Human 100.00 19051271
52 twist1 13.6 runx2 28.4 Human 100.00 21503964
53 twist1 13.6 f2r 3.5 Human 100.00 19051271
54 twist1 13.6 timp1 6.8 Human 100.00 19513566